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  1. Research article

    Antiproliferative and apoptotic effects of black turtle bean extracts on human breast cancer cell line through extrinsic and intrinsic pathway

    The black turtle bean (BTB) is most widely consumed legume all over the world having anticancer activity. The aim of the study was to analyse the apoptotic effects of BTB extracts on human breast cancer cell l...

    Suresh Kumar, Vinay Kumar Sharma, Savita Yadav and Sharmistha Dey

    Chemistry Central Journal 2017 11:56

    Published on: 20 June 2017

  2. Research article

    Effects of temperature, time, and solvent ratio on the extraction of phenolic compounds and the anti-radical activity of Clinacanthus nutans Lindau leaves by response surface methodology

    Clinacanthus nutans Lindau is a well-known plant, native to tropical Asian countries. Reports on this plant that is rich in phenolic compounds have focused on its therapeutic anti-infl...

    Intan Soraya Che Sulaiman, Mahiran Basri, Hamid Reza Fard Masoumi, Wei Jian Chee, Siti Efliza Ashari and Maznah Ismail

    Chemistry Central Journal 2017 11:54

    Published on: 14 June 2017

  3. Research article

    Synthesis of some new pyrazolo[1,5-a]pyrimidine, pyrazolo[5,1-c]triazine, 1,3,4-thiadiazole and pyridine derivatives containing 1,2,3-triazole moiety

    Pyrazolo[1,5-a]pyrimidines are purine analogues. They have beneficial properties as antimetabolites in purine biochemical reactions. This division compounds have attracted wide pharmaceutical interest because of ...

    Nadia A. Abdelriheem, Yasser H. Zaki and Abdou O. Abdelhamid

    Chemistry Central Journal 2017 11:53

    Published on: 12 June 2017

  4. Research article

    Synthesis, characterization, X-ray structure, computational studies, and bioassay of novel compounds combining thiophene and benzimidazole or 1,2,4-triazole moieties

    Due to their interesting and versatile biological activity, thiophene-containing compounds have attracted the attention of both chemists and medicinal chemists. Some of these compounds have anticancer, antibac...

    Yahia N. Mabkhot, Salim S. Al-Showiman, Saied M. Soliman, Hazem A. Ghabbour, Murad A. AlDamen and Mohammad S. Mubarak

    Chemistry Central Journal 2017 11:51

    Published on: 9 June 2017

  5. Research article

    Synthesis and insecticidal activity of diacylhydrazine derivatives containing a 3-bromo-1-(3-chloropyridin-2-yl)-1H-pyrazole scaffold

    The diacylhydrazine derivatives have attracted considerable attention in recently years due to their simple structure, low toxicity, and high insecticidal selectivity. As well as 3-bromo-1-(3-chloropyridin-2-y...

    Yanyan Wang, Fangzhou Xu, Gang Yu, Jun Shi, Chuanhui Li, A’li Dai, Zhiqian Liu, Jiahong Xu, Fenghua Wang and Jian Wu

    Chemistry Central Journal 2017 11:50

    Published on: 5 June 2017

  6. Research article

    Molecular docking and biological evaluation of some thioxoquinazolin-4(3H)-one derivatives as anticancer, antioxidant and anticonvulsant agents

    The quinazoline are an important class of medicinal compounds that possess a number of biological activities like anticancer, anticonvulsant and antioxidant etc.

    Danah S. Al-Shamary, Monirah A. Al-Alshaikh, Nabila Abdelshafy Kheder, Yahia Nasser Mabkhot and Syed Lal Badshah

    Chemistry Central Journal 2017 11:48

    Published on: 31 May 2017

  7. Research article

    Morphologically controlled synthesis of ferric oxide nano/micro particles and their catalytic application in dry and wet media: a new approach

    Morphologically controlled synthesis of ferric oxide nano/micro particles has been carried out by using solvothermal route. Structural characterization displays that the predominant morphologies are porous hol...

    Muhammad Ramzan Saeed Ashraf Janjua, Saba Jamil, Nazish Jahan, Shanza Rauf Khan and Saima Mirza

    Chemistry Central Journal 2017 11:49

    Published on: 31 May 2017

  8. Research article

    Liquid chromatography tandem mass spectrometry method for the quantification of vandetanib in human plasma and rat liver microsomes matrices: metabolic stability investigation

    Vandetanib (VNT) is a new oral tyrosine kinase inhibitor that acts mainly by inhibiting vascular endothelial growth factor receptor (VEGFR). Fast, specific, sensitive and validated LC–MS/MS was established for...

    Sawsan M. Amer, Adnan A. Kadi, Hany W. Darwish and Mohamed W. Attwa

    Chemistry Central Journal 2017 11:45

    Published on: 30 May 2017

  9. Review

    Gadolinium-based layered double hydroxide and graphene oxide nano-carriers for magnetic resonance imaging and drug delivery

    Gadolinium (Gd)-based contrasts remain one of the most accepted contrast agents for magnetic resonance imaging, which is among the world most recognized noninvasive techniques employed in clinical diagnosis of...

    Muhammad Sani Usman, Mohd Zobir Hussein, Sharida Fakurazi and Fathinul Fikri Ahmad Saad

    Chemistry Central Journal 2017 11:47

    Published on: 30 May 2017

  10. Research article

    Optimization of enzymatic esterification of dihydrocaffeic acid with hexanol in ionic liquid using response surface methodology

    Developing an efficient lipophilization reaction system for phenolic derivatives could enhance their applications in food processing. Low solubility of phenolic acids reduces the efficiency of phenolic derivat...

    Somayeh Gholivand, Ola Lasekan, Chin Ping Tan, Faridah Abas and Leong Sze Wei

    Chemistry Central Journal 2017 11:44

    Published on: 26 May 2017

  11. Research article

    Different applications of isosbestic points, normalized spectra and dual wavelength as powerful tools for resolution of multicomponent mixtures with severely overlapping spectra

    Analysis of complex mixture containing three or more components represented a challenge for analysts. New smart spectrophotometric methods have been recently evolved with no limitation. A study of different no...

    Ekram H. Mohamed, Hayam M. Lotfy, Maha A. Hegazy and Shereen Mowaka

    Chemistry Central Journal 2017 11:43

    Published on: 25 May 2017

  12. Research article

    QSAR studies on PIM1 and PIM2 inhibitors using statistical methods: a rustic strategy to screen for 5-(1H-indol-5-yl)-1,3,4-thiadiazol analogues and predict their PIM inhibitory activity

    Quantitative structure activity relationship was carried out to study a series of PIM1 and PIM2 inhibitors. The present study was performed on twenty-five substituted 5-(1H-indol-5-yl)-1,3,4-thiadiazols as PIM...

    Adnane Aouidate, Adib Ghaleb, Mounir Ghamali, Samir Chtita, M’barek Choukrad, Abdelouahid Sbai, Mohammed Bouachrine and Tahar Lakhlifi

    Chemistry Central Journal 2017 11:41

    Published on: 19 May 2017

  13. Research article

    Synthesis, docking study and biological evaluation of some new thiourea derivatives bearing benzenesulfonamide moiety

    A series of novel N-(2, 6-dimethoxypyrimidin-4-yl)-4-(3-(aryl)thioureido) benzenesulfonamides 3at was synthesized by the addition of N-(2,6-dimethoxypyrimidin-4-yl)-4-isothiocyanatobenzenesulfonamide 2 to the ap...

    Mostafa M. Ghorab, Mohamed S. A. El-Gaby, Aiten M. Soliman, Mansour S. Alsaid, Marwa M. Abdel-Aziz and Mahmoud M. Elaasser

    Chemistry Central Journal 2017 11:42

    Published on: 19 May 2017

  14. Research article

    Synthesis, characterization and evaluation of 1,3,5-triazine aminobenzoic acid derivatives for their antimicrobial activity

    Replacement of chloride ions in cyanuric chloride give several variants of 1,3,5-triazine derivatives which were investigated as biologically active small molecules. These compounds exhibit antimalarial, antim...

    Khadijah M. Al-Zaydi, Hosam H. Khalil, Ayman El-Faham and Sherine N. Khattab

    Chemistry Central Journal 2017 11:39

    Published on: 10 May 2017

  15. Research article

    Synthesis, crystallographic, spectroscopic studies and biological activity of new cobalt(II) complexes with bioactive mixed sulindac and nitrogen-donor ligands

    Four novel complexes [Co(H2O)4(sul)2] 1, [Co(2-ampy)2(sul)2] 2, [Co(H2O)2(1,10-phen) (sul)2] 3 and [Co(2,9-dimephen)(sul)2] 4 (sul = sulindac, 2-ampy = 2-amino pyridine, 1,10-phen = 1,10-phenanthroline and 2,9-di...

    Asia M. Shalash and Hijazi I. Abu Ali

    Chemistry Central Journal 2017 11:40

    Published on: 10 May 2017

  16. Research article

    Application of a strategy based on metabolomics guided promoting blood circulation bioactivity compounds screening of vinegar

    Rice vinegar (RV) and white vinegar (WV) as daily flavoring, have also used as accessory in traditional Chinese medicine processing. As we know, the promoting blood circulation efficiency could be enhanced whe...

    Zhangchi Ning, Zhenli Liu, Zhiqian Song, Chun Wang, Yuanyan Liu, Jiahe Gan, Xinling Ma and Aiping Lu

    Chemistry Central Journal 2017 11:38

    Published on: 8 May 2017

  17. Research article

    Rapid simultaneous determination of indacaterol maleate and glycopyrronium bromide in inhaler capsules using a validated stability-indicating monolithic LC method

    Chronic obstructive pulmonary disease (COPD) is a major cause of morbidity and mortality worldwide. A combination of indacaterol maleate with glycopyrronium bromide has recently been approved as a once-daily m...

    Sahar Zayed and Fathalla Belal

    Chemistry Central Journal 2017 11:36

    Published on: 4 May 2017

  18. Research article

    Natural product based composite for extraction of arsenic (III) from waste water

    Natural based composites of hydroxyapatite/Gum Arabic designed for removal of toxic metal arsenic (III) from waste water were synthesized and evaluated. Several composites with various compositions were prepar...

    N. Akartasse, E. Mejdoubi, B. Razzouki, K. Azzaoui, S. Jodeh, O. Hamed, M. Ramdani, A. Lamhamdi, M. Berrabah, I. Lahmass, W. Jodeh and S. El Hajjaji

    Chemistry Central Journal 2017 11:33

    Published on: 12 April 2017

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