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  1. Research article

    Comprehensive spectral identification of key intermediates to the final product of the chiral pool synthesis of radezolid

    Radezolid (RAD, 12), biaryl oxazolidinone, was synthesised with small modifications according to the methods described in the literature. The pharmacological activity is observed only for (S)-enantiomer, therefor...

    Katarzyna Michalska, Elżbieta Bednarek, Ewa Gruba, Kornelia Lewandowska, Mikołaj Mizera and Judyta Cielecka-Piontek

    Chemistry Central Journal 2017 11:82

    Published on: 9 August 2017

  2. Research article

    One-step multicomponent synthesis of chiral oxazolinyl-zinc complexes

    Typically, oxazolinyl metal complexes are synthesized in two steps, where the free ligand is prepared by the condensation reaction between a functionalized nitrile and an amino alcohol in the presence of a Lew...

    Mei Luo, Jing Cheng Zhang, Wen Min Pang and King Kuok Hii

    Chemistry Central Journal 2017 11:81

    Published on: 9 August 2017

  3. Research article

    Bis-pyrimidine acetamides: design, synthesis and biological evaluation

    In the past few years, increased resistance of microorganisms towards antimicrobial agents become a serious health problem, so there is a need for the discovery of new antimicrobial agents. On the other hand, ...

    Sanjiv Kumar, Siong Meng Lim, Kalavathy Ramasamy, Mani Vasudevan, Syed Adnan Ali Shah and Balasubramanian Narasimhan

    Chemistry Central Journal 2017 11:80

    Published on: 8 August 2017

  4. Research article

    Comparison of various techniques for the extraction of umbelliferone and herniarin in Matricaria chamomilla processing fractions

    Chamomile, a well-known medicinal plant, is a rich source of bioactive compounds, among which two coumarin derivatives, umbelliferone and herniarin, are often found in its extracts. Chamomile extracts have fou...

    Maja Molnar, Nikolina Mendešević, Drago Šubarić, Ines Banjari and Stela Jokić

    Chemistry Central Journal 2017 11:78

    Published on: 5 August 2017

  5. Research article

    Antimicrobial activity of thiophene derivatives derived from ethyl (E)-5-(3-(dimethylamino)acryloyl)-4-methyl-2-(phenylamino)thiophene-3-carboxylate

    The thiophene nucleus has been recognized as an important entity in the synthesis of heterocyclic compounds with promising pharmacological characteristics.

    Yahia Nasser Mabkhot, Nahed Ahmed Kaal, Seham Alterary, Salem S. Al-Showiman, Thoraya A. Farghaly and Mohammad S. Mubarak

    Chemistry Central Journal 2017 11:75

    Published on: 3 August 2017

  6. Research article

    Regioselective semi-synthesis of 6-isomers of 5,8-O-dimethyl ether of shikonin derivatives via an ‘intramolecular ring-closing/ring-opening’ strategy as potent anticancer agents

    Synthesis of 6-isomer of 5,8-O-dimethyl ether of shikonin (13), a promising anticancer scaffold, always remains a huge challenge. Herein a key intermediate for 13, 2-(1-hydroxyl-4-methyl-3-pentenyl)-1,4,5,8-tetra...

    Li Zhou, Xu Zhang and Wen Zhou

    Chemistry Central Journal 2017 11:74

    Published on: 2 August 2017

  7. Research article

    Ultra-high resolution X-ray structures of two forms of human recombinant insulin at 100 K

    The crystal structure of a commercially available form of human recombinant (HR) insulin, Insugen (I), used in the treatment of diabetes has been determined to 0.92 Å resolution using low temperature, 100 K, s...

    David R. Lisgarten, Rex A. Palmer, Carina M. C. Lobley, Claire E. Naylor, Babur Z. Chowdhry, Zakieh I. Al-Kurdi, Adnan A. Badwan, Brendan J. Howlin, Nicholas C. J. Gibbons, José W. Saldanha, John N. Lisgarten and Ajit K. Basak

    Chemistry Central Journal 2017 11:73

    Published on: 1 August 2017

  8. Research article

    Structural optimization and evaluation of novel 2-pyrrolidone-fused (2-oxoindolin-3-ylidene)methylpyrrole derivatives as potential VEGFR-2/PDGFRβ inhibitors

    Tumor angiogenesis, essential for tumor growth and metastasis, is tightly regulated by VEGF/VEGFR and PDGF/PDGFR pathways, and therefore blocking those pathways is a promising therapeutic target. Compared to s...

    Ting-Hsuan Yang, Chun-I Lee, Wen-Hsin Huang and An-Rong Lee

    Chemistry Central Journal 2017 11:72

    Published on: 1 August 2017

  9. Research article

    Structural effects on kinetics and a mechanistic investigation of the reaction between DMAD and N–H heterocyclic compound in the presence of triphenylarsine: spectrophotometry approach

    Kinetics and a mechanistic investigation of the reaction between dimethyl acetylenedicarboxcylate (DMAD) and saccharin (NH heterocyclic compound) has been spectrally studied in methanol environment in the presen...

    Sayyed Mostafa Habibi-Khorassani, Mehdi Shahraki and Mahdieh Darijani

    Chemistry Central Journal 2017 11:71

    Published on: 1 August 2017

  10. Research article

    Novel drug targets for Mycobacterium tuberculosis: 2-heterostyrylbenzimidazoles as inhibitors of cell wall protein synthesis

    Multi drug-resistant and mycobacterial infections are a major public health challenge, leading to high mortality and socioeconomic burdens through worldwide. Novel therapeutics are necessary to treat the drug ...

    Mohana Rao Anguru, Ashok Kumar Taduri, Rama Devi Bhoomireddy, Malathi Jojula and Shravan Kumar Gunda

    Chemistry Central Journal 2017 11:68

    Published on: 24 July 2017

  11. Research article

    One pot synthesis, antimicrobial and antioxidant activities of fused uracils: pyrimidodiazepines, lumazines, triazolouracil and xanthines

    Uracil derivatives have a great attraction because they play an important role in pharmacological activities. Pyrimidodiazepines, lumazines, triazolopyrimidines and xanthines have significant wide spectrum act...

    Samar A. El-Kalyoubi, Eman A. Fayed and Ahmed S. Abdel-Razek

    Chemistry Central Journal 2017 11:66

    Published on: 19 July 2017

    The Erratum to this article has been published in Chemistry Central Journal 2017 11:69

  12. Methodology

    RD-Metabolizer: an integrated and reaction types extensive approach to predict metabolic sites and metabolites of drug-like molecules

    Experimental approaches for determining the metabolic properties of the drug candidates are usually expensive, time-consuming and labor intensive. There is a great deal of interest in developing computational ...

    Jiajia Meng, Shiliang Li, Xiaofeng Liu, Mingyue Zheng and Honglin Li

    Chemistry Central Journal 2017 11:65

    Published on: 18 July 2017

  13. Research article

    Comparative study of phenolic compounds, vitamin E, and fatty acids compositional profiles in black seed-coated soybeans (Glycine Max (L.) Merrill) depending on pickling period in brewed vinegar

    Pickled soybeans or vinegar beans have long been used as a folk remedy and also a supplemental nutritional source in Korea. In general the pickling process in vinegar improves the digestibility of soybeans as ...

    Ill-Min Chung, Jin-Young Oh and Seung-Hyun Kim

    Chemistry Central Journal 2017 11:64

    Published on: 18 July 2017

  14. Research article

    Using crystallography, topology and graph set analysis for the description of the hydrogen bond network of triamterene: a rational approach to solid form selection

    This study has demonstrated the use of crystallography, topology and graph set analysis in the description and classification of the complex hydrogen bonded network of triamterene. The aim is to give a brief o...

    David S. Hughes, Amit Delori, Abida Rehman and William Jones

    Chemistry Central Journal 2017 11:63

    Published on: 13 July 2017

  15. Review

    Selective synthesis of Fe3O4Au x Ag y nanomaterials and their potential applications in catalysis and nanomedicine

    In these recent years, magnetite (Fe3O4) has witnessed a growing interest in the scientific community as a potential material in various fields of application namely in catalysis, biosensing, hyperthermia treatme...

    Essy Kouadio Fodjo, Koffi Mouroufié Gabriel, Brou Yapi Serge, Dan Li, Cong Kong and Albert Trokourey

    Chemistry Central Journal 2017 11:58

    Published on: 24 June 2017

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