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  1. Review

    Biological potential of thiazolidinedione derivatives of synthetic origin

    Thiazolidinediones are sulfur containing pentacyclic compounds that are widely found throughout nature in various forms. Thiazolidinedione nucleus is present in numerous biological compounds, e.g., anti-malari...

    Sucheta, Sumit Tahlan and Prabhakar Kumar Verma

    Chemistry Central Journal 2017 11:130

    Published on: 8 December 2017

  2. Research article

    Synthesis, structure and toxicity evaluation of ethanolamine nitro/chloronitrobenzoates: a combined experimental and theoretical study

    Nitroaromatic and chloronitroaromatic compounds have been a subject of great interest in industry and recently in medical-pharmaceutic field. 2-Chloro-4-nitro/2-chloro-5-nitrobenzoic acids and 4-nitrobenzoic a...

    Manuela Crisan, Liliana Halip, Paulina Bourosh, Sergiu Adrian Chicu and Yurii Chumakov

    Chemistry Central Journal 2017 11:129

    Published on: 6 December 2017

  3. Research Article

    Synthesis and analytical characterization of new thiazol-2-(3H)-ones as human neutrophil elastase (HNE) inhibitors

    Human neutrophil elastase (HNE) is a potent serine protease belonging to the chymotrypsin family and is involved in a variety of pathologies affecting the respiratory system. Thus, compounds able to inhibit HN...

    Letizia Crocetti, Gianluca Bartolucci, Agostino Cilibrizzi, Maria Paola Giovannoni, Gabriella Guerrini, Antonella Iacovone, Marta Menicatti, Igor A. Schepetkin, Andrei I. Khlebnikov, Mark T. Quinn and Claudia Vergelli

    Chemistry Central Journal 2017 11:127

    Published on: 6 December 2017

  4. Research article

    Investigating and characterizing the binding activity of the immobilized calmodulin to calmodulin-dependent protein kinase I binding domain with atomic force microscopy

    Protein–protein interactions are responsible for many biological processes, and the study of how proteins undergo a conformational change induced by other proteins in the immobilized state can help us to under...

    Xiaoning Zhang and Hongmei Hu

    Chemistry Central Journal 2017 11:128

    Published on: 6 December 2017

  5. Research Article

    Development of new analytical methods for the determination of caffeine content in aqueous solution of green coffee beans

    This study was conducted to develop fast and cost effective methods for the determination of caffeine in green coffee beans. In the present work direct determination of caffeine in aqueous solution of green co...

    Blen Weldegebreal, Mesfin Redi-Abshiro and Bhagwan Singh Chandravanshi

    Chemistry Central Journal 2017 11:126

    Published on: 5 December 2017

  6. Research Article

    Structure-dependent optoelectronic properties of perylene, di-indenoperylene (DIP) isolated molecule and DIP molecular crystal

    Theoretical simulations were designed by first principles approach of density functional theory to investigate the structural and optoelectronic properties of different structural classes of perylene; isolated...

    Mazmira Mohamad, Rashid Ahmed, Amirudin Shaari and Souraya Goumri-Said

    Chemistry Central Journal 2017 11:125

    Published on: 2 December 2017

  7. Research Article

    An improved solvent-free synthesis of flunixin and 2-(arylamino) nicotinic acid derivatives using boric acid as catalyst

    A simple solvent-free protocol for the preparation of flunixin, a potent non-narcotic, non-steroidal anti-inflammatory drugs is reported using boric acid as catalyst. Its salt, flunixin meglumine are then prep...

    Mahsa Yarhosseini, Shahrzad Javanshir, Zahra Dolatkhah and Mohammad G. Dekamin

    Chemistry Central Journal 2017 11:124

    Published on: 1 December 2017

  8. Research Article

    Synthesis, anti-angiogenic and DNA cleavage studies of novel N-(4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)piperidine-4-carboxamide derivatives

    A series of novel N-(4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)piperidine-4-carboxamide derivatives 10(af), 12(ac) and 14(ac) were synthesized and characterized by FTIR, 1H-NMR, mass spectral an...

    Vinaya Kambappa, G. K. Chandrashekara, N. D. Rekha, Prasanna D. Shivaramu and Komaraiah Palle

    Chemistry Central Journal 2017 11:122

    Published on: 30 November 2017

  9. Correction

    Correction to: Synthesis, characterization and in vitro antimicrobial activity of novel fused pyrazolo[3,4-c]pyridazine, pyrazolo[3,4-d]pyrimidine, thieno[3,2-c] pyrazole and pyrazolo[3′,4′:4,5]thieno[2,3-d]pyrimidine derivatives

    After the publication of this work [1] it was noticed that on page 3 of the article beginning in the paragraph—‘Hydrazide 14 is used as a key producer…’ the compound—“Not ethyl-N′-5-amino-1,3-diphenyl-1H-thieno[3...

    Mohamed A. M. Abdel Reheim and Safaa M. Baker

    Chemistry Central Journal 2017 11:123

    Published on: 30 November 2017

    The original article was published in Chemistry Central Journal 2017 11:112

  10. Research Article

    Determination of lesinurad in rat plasma by a UHPLC–MS/MS assay

    Lesinurad is an oral inhibitor of urate-anion exchanger transporter 1 and has been approved by the US Food and Drug Administration for combination therapy with a xanthine oxidase inhibitor for the treatment of...

    Xiao-Yang Zhou, Ling-Jing Yuan, Zhe Chen, Peng-Fei Tang, Xiang-Yu Li, Guo-Xin Hu and Jian-Ping Cai

    Chemistry Central Journal 2017 11:121

    Published on: 28 November 2017

  11. Research article

    Electrochemical behavior and in-vitro antimicrobial screening of some thienylazoaryls dyes

    A series of recently reported phenolic azo dyes 7a–e were prepared by coupling the thienyl diazonium sulfate of 3-Amino-4H-benzo[f]thieno[3,4-c](2H)chromen-4-one with selected diversely substituted phenolic and n...

    Joseph Tsemeugne, Emmanuel Sopbué Fondjo, Jean-de-Dieu Tamokou, Ignas Tonle, Irene Chinda Kengne, Arnaud Djintchui Ngongang, Stephen Tamekou Lacmata, Taoufik Rohand, Jules Roger Kuiate and Beibam Luc Sondengam

    Chemistry Central Journal 2017 11:119

    Published on: 21 November 2017

  12. Research article

    Polysaccharides from Dolichos biflorus Linn and Trachyspermum ammi Linn seeds: isolation, characterization and remarkable antimicrobial activity

    Polysaccharides are structurally complex and essential constituents of life, and therefore, studies directed to these kinds of molecules have received scientific attention. Despite an easy availability of Dolicho...

    Shibani Basu, Manojit Ghosh, Rupam Kumar Bhunia, Jhuma Ganguly and Bimal K. Banik

    Chemistry Central Journal 2017 11:118

    Published on: 21 November 2017

  13. Research article

    Study on the interaction of paeoniflorin with human serum albumin (HSA) by spectroscopic and molecular docking techniques

    The interaction of paeoniflorin with human serum albumin (HSA) was investigated using fluorescence, UV–vis absorption, circular dichroism (CD) spectra and molecular docking techniques under simulative physiolo...

    Liang Xu, Yan-Xi Hu, Yan-Cheng Li, Yu-Feng Liu, Li Zhang, Hai-Xin Ai and Hong-Sheng Liu

    Chemistry Central Journal 2017 11:116

    Published on: 17 November 2017

  14. Research article

    Design, synthesis, conformational and molecular docking study of some novel acyl hydrazone based molecular hybrids as antimalarial and antimicrobial agents

    Acyl hydrazones are an important class of heterocyclic compounds promising pharmacological characteristics. Malaria is a life-threatening mosquito-borne blood disease caused by a plasmodium parasite. In some p...

    Parvin Kumar, Kulbir Kadyan, Meenakshi Duhan, Jayant Sindhu, Vineeta Singh and Baljeet Singh Saharan

    Chemistry Central Journal 2017 11:115

    Published on: 14 November 2017

  15. Research article

    Simultaneous determination of brazilin and protosappanin B in Caesalpinia sappan by ionic-liquid dispersive liquid-phase microextraction method combined with HPLC

    The conditions of heating, ionic liquid-based ultrasonic-assisted extraction combined with reverse-phase high performance liquid chromatography were optimized to simultaneously isolate and determinate brazilin...

    Zhaoyang Xia, Dongdong Li, Qing Li, Yan Zhang and Wenyi Kang

    Chemistry Central Journal 2017 11:114

    Published on: 13 November 2017

  16. Research article

    Antimicrobial and antioxidant potential of different solvent extracts of the medicinal plant Geum urbanum L.

    Many Geum species are known to be rich in biologically active compounds and therefore could be a source of new natural products with pharmacological potential. The medicinal plant Geum urbanum L. is widespread in...

    Lyudmila Dimitrova, Maya M. Zaharieva, Milena Popova, Nedelina Kostadinova, Iva Tsvetkova, Vassya Bankova and Hristo Najdenski

    Chemistry Central Journal 2017 11:113

    Published on: 7 November 2017

  17. Research article

    Synthesis, characterization and in vitro antimicrobial activity of novel fused pyrazolo[3,4-c]pyridazine, pyrazolo[3,4-d]pyrimidine, thieno[3,2-c]pyrazole and pyrazolo[3′,4′:4,5]thieno[2,3-d]pyrimidine derivatives

    Some novel substituted pyrazolone, pyrazolo[3,4-c]pyridazine, pyrazolo[3,4-d]pyrimidine, pyrazolo[3,4-d]thiazolo[3,2-a]pyrimidinone, thieno[3,2-c]pyrazole and pyrazolo[3′,4′:4,5]thieno[2,3-d]pyrimidine derivative...

    Mohamed A. M. Abdel Reheim and Safaa M. Baker

    Chemistry Central Journal 2017 11:112

    Published on: 2 November 2017

    The Correction to this article has been published in Chemistry Central Journal 2017 11:123

  18. Research article

    Aromatherapy: composition of the gaseous phase at equilibrium with liquid bergamot essential oil

    This work compares the composition at different temperatures of gaseous phase of bergamot essential oil at equilibrium with the liquid phase. A new GC–MS methodology to determine quantitatively the volatile ar...

    Antonella Leggio, Vanessa Leotta, Emilia Lucia Belsito, Maria Luisa Di Gioia, Emanuela Romio, Ilaria Santoro, Domenico Taverna, Giovanni Sindona and Angelo Liguori

    Chemistry Central Journal 2017 11:111

    Published on: 2 November 2017

  19. Research article

    Antioxidant and antiproliferative activity of blue corn and tortilla from native maize

    Blue corn is a cereal rich in phenolic compounds used to make blue tortillas. Tortillas are an important part of the Mexican diet. Blue corn and tortilla represent an important source of the natural antioxidan...

    Mónica Y. Herrera-Sotero, Carlos D. Cruz-Hernández, Carolina Trujillo-Carretero, Mauricio Rodríguez-Dorantes, Hugo S. García-Galindo, José L. Chávez-Servia, Rosa M. Oliart-Ros and Rosa I. Guzmán-Gerónimo

    Chemistry Central Journal 2017 11:110

    Published on: 30 October 2017

  20. Research article

    Synthesis and biological activity of myricetin derivatives containing 1,3,4-thiadiazole scaffold

    Myricetin and 1,3,4-thiadiazole derivatives were reported to exhibit favorable antiviral and antibacterial activities. Aiming to discover novel myricetin analogues with potent activities, a series of novel myr...

    Xinmin Zhong, Xiaobin Wang, Lijuan Chen, Xianghui Ruan, Qin Li, Juping Zhang, Zhuo Chen and Wei Xue

    Chemistry Central Journal 2017 11:106

    Published on: 17 October 2017

  21. Research article

    Preparative HPLC for large scale isolation, and salting-out assisted liquid–liquid extraction based method for HPLC–DAD determination of khat (Catha edulis Forsk) alkaloids

    Khat (Catha edulis Forsk) is an evergreen shrub of the Celastraceae family. It is widely cultivated in Yemen and East Africa, where its fresh leaves are habitually chewed for their momentary pleasures and stimula...

    Minaleshewa Atlabachew, Bhagwan Singh Chandravanshi and Mesfin Redi-Abshiro

    Chemistry Central Journal 2017 11:107

    Published on: 17 October 2017

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