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Featured article: Crystal structure, DFT calculations and evaluation of 2-(2-(3,4-dimethoxyphenyl)ethyl)isoindoline-1,3-dione as AChE inhibitor

In this study, 2-(2-(3,4-dimethoxyphenyl)ethyl)isoindoline-1,3-dione was synthesized, crystallized and evaluated as an inhibitor of AChE: a key enzyme involved in the deterioration of the cholinergic system during the development of Alzheimer’s disease. The geometric structure of the crystal and the theoretical compound were analyzed and compared, finding a close correlation. In addition, biological experiments reveal that the isoindoline-1,3-dione exerts a good competitive inhibition on AChE and has very low acute toxicity compared to the AChE inhibitors currently approved for clinical use.


  1. Content type: Review


    Authors: Andrew SID Lang and Jean-Claude Bradley

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Chemistry Central Journal publishes peer-reviewed open-access articles in all areas of chemistry. The journal comprises nine subject sections:

Editors' Profiles

R. Stephen Berry is James Franck Distinguished Service Professor Emeritus in Chemistry at the University of Chicago.

Research interests include the study of protein folding and interaction, atomic collisions, thermodynamics, efficient use of energy resources, nanoscale particle behavior, and intellectual property and electronic scientific communication.

King Kuok (Mimi) Hii is Professor of Catalysis at Imperial College London.

Research interests include the development of catalytic methodologies for atom- and step-efficient synthesis.


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