Chemistry Central Journal

Featured article: Crystal structure, DFT calculations and evaluation of 2-(2-(3,4-dimethoxyphenyl)ethyl)isoindoline-1,3-dione as AChE inhibitor

In this study, 2-(2-(3,4-dimethoxyphenyl)ethyl)isoindoline-1,3-dione was synthesized, crystallized and evaluated as an inhibitor of AChE: a key enzyme involved in the deterioration of the cholinergic system during the development of Alzheimer’s disease. The geometric structure of the crystal and the theoretical compound were analyzed and compared, finding a close correlation. In addition, biological experiments reveal that the isoindoline-1,3-dione exerts a good competitive inhibition on AChE and has very low acute toxicity compared to the AChE inhibitors currently approved for clinical use.

Content type: Research Article
| 19 July 2018

Simultaneous determination of five azadirachtins in the seed and leaf extracts of Azadirachta indica by automated online solid-phase extraction coupled with LC–Q-TOF–MS

Authors: Li Song, Jin Wang, Quan Gao, Xiaojiang Ma, Yuwei Wang, Yaoyao Zhang, Hang Xun, Xi Yao and Feng Tang
Content type: Research Article
| 17 July 2018

Design and synthesis of novel 3-(thiophen-2-yl)-1,5-dihydro-2H-pyrrol-2-one derivatives bearing a hydrazone moiety as potential fungicides

Authors: Xiaobin Wang, Zhengjiao Ren, Mengqi Wang, Min Chen, Aiming Lu, Weijie Si and Chunlong Yang
Content type: Research Article
| 17 July 2018

Facile synthesis of N- (4-bromophenyl)-1- (3-bromothiophen-2-yl)methanimine derivatives via Suzuki cross-coupling reaction: their characterization and DFT studies

Authors: Komal Rizwan, Nasir Rasool, Ravya Rehman, Tariq Mahmood, Khurshid Ayub, Tahir Rasheed, Gulraiz Ahmad, Ayesha Malik, Shakeel Ahmad Khan, Muhammad Nadeem Akhtar, Noorjahan Banu Alitheen and Muhammad Nazirul Mubin Aziz
Content type: Research Article
| 12 July 2018

Inhibitory effects against α-glucosidase and α-amylase of the flavonoids-rich extract from Scutellaria baicalensis shoots and interpretation of structure–activity relationship of its eight flavonoids by a refined assign-score method

Authors: Ke Li, Fan Yao, Qiang Xue, Hang Fan, Lingguang Yang, Xiang Li, Liwei Sun and Yujun Liu
Content type: Research Article
| 11 July 2018

Removal of malachite green from aqueous solution using pulverized teak leaf litter: equilibrium, kinetic and thermodynamic studies

Authors: Emmanuel O. Oyelude, Johannes A. M. Awudza and Sylvester K. Twumasi

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Content type: Review
| 23 October 2009

Chemistry in Second Life

Authors: Andrew SID Lang and Jean-Claude Bradley
Content type: Research article
| 27 February 2013

TiO₂-graphene oxide nanocomposite as advanced photocatalytic materials

Authors: Václav Štengl, Snejana Bakardjieva, Tomáš Matys Grygar, Jana Bludská and Martin Kormunda
Content type: Research article
| 25 November 2014

Anthraquinonyl glycoside facilitates the standardization of graphene electrodes for the impedance detection of lectins

Authors: Bi-Wen Zhu, Liang Cai, Xiao-Peng He, Guo-Rong Chen and Yi-Tao Long
Content type: Research article
| 4 March 2013

Transformation of PVP coated silver nanoparticles in a simulated wastewater treatment process and the effect on microbial communities

Authors: Casey L Doolette, Mike J McLaughlin, Jason K Kirby, Damien J Batstone, Hugh H Harris, Huoqing Ge and Geert Cornelis
Content type: Review
| 25 February 2013

Carnosine: can understanding its actions on energy metabolism and protein homeostasis inform its therapeutic potential?

Authors: Alan R Hipkiss, Stephanie P Cartwright, Clare Bromley, Stephane R Gross and Roslyn M Bill

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Aims and Scope

Chemistry Central Journal publishes peer-reviewed open-access articles in all areas of chemistry. The journal comprises nine subject sections:

Editors' Profiles

R. Stephen Berry is James Franck Distinguished Service Professor Emeritus in Chemistry at the University of Chicago.

Research interests include the study of protein folding and interaction, atomic collisions, thermodynamics, efficient use of energy resources, nanoscale particle behavior, and intellectual property and electronic scientific communication.

King Kuok (Mimi) Hii is Professor of Catalysis at Imperial College London.

Research interests include the development of catalytic methodologies for atom- and step-efficient synthesis.