Favipiravir® 400 mg/tablet | Moxinow® 400 & 400 mg/tablet | Co-formulated dosage form | |||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
FPV | CEF | MFX | FPV | CEF | MFX | ||||||||||||
Conc (μg/mL) | PLS % R* | GA-PLS % R* | Conc (μg/mL) | PLS % R* | GA-PLS % R* | Conc (μg/mL) | PLS % R* | GA-PLS % R* | Conc (μg/mL) | PLS % R* | GA-PLS % R* | Conc (μg/mL) | PLS % R* | GA-PLS % R* | Conc (μg/mL) | PLS % R* | GA-PLS % R* |
3 | 97.65 | 99.31 | 3 | 100.59 | 101.24 | 3 | 98.94 | 99.45 | 3 | 101.46 | 100.60 | 3 | 102.21 | 98.17 | 3 | 98.20 | 101.13 |
4 | 101.13 | 98.42 | 4 | 99.79 | 100.96 | 4 | 101.36 | 100.87 | 4 | 99.73 | 98.84 | 4 | 101.59 | 97.69 | 4 | 97.48 | 100.45 |
5 | 100.46 | 100.15 | 5 | 97.56 | 98.54 | 5 | 101.81 | 98.39 | 5 | 101.34 | 100.44 | 5 | 101.46 | 97.44 | 5 | 99.32 | 102.24 |
6 | 99.52 | 99.83 | 6 | 101.47 | 101.63 | 6 | 100.48 | 101.17 | 6 | 100.86 | 99.99 | 6 | 101.39 | 97.38 | 6 | 98.38 | 101.24 |
7 | 100.78 | 100.95 | 7 | 98.12 | 99.75 | 7 | 99.65 | 100.86 | 7 | 101.34 | 100.46 | 7 | 101.51 | 97.48 | 7 | 98.79 | 101.68 |
Mean | 99.91 | 99.73 | Mean | 99.51 | 100.42 | Mean | 100.45 | 100.15 | Mean | 100.94 | 100.07 | Mean | 101.63 | 97.63 | Mean | 98.43 | 101.35 |
%RSD | 1.398 | 0.947 | %RSD | 1.653 | 1.261 | %RSD | 1.178 | 1.187 | %RSD | 0.713 | 0.722 | %RSD | 0.327 | 0.333 | %RSD | 0.698 | 0.656 |