Table 10 Greenness assessment of the proposed and HPLC-reported techniques utilizing the Eco-scale and GAPI tools
Parameters | Proposed Chemometric method | Reported method for FPV (HPLC) [10] | Reported method for FPV (spectrophotometry) [42] | Reported method for CEF and MFX [23] | ||
|---|---|---|---|---|---|---|
Application | Pharmaceutical dosage forms | Spiked human plasma | Pharmaceutical dosage forms | Pharmaceutical dosage forms | Spiked human plasma | Pharmaceutical dosage forms |
Reagents | Â | Â | Â | Â | Â | Â |
Water | 0 | 0 | – | – | – | 0 |
Methanol | – | 6 | 12 | – | – | – |
Acetonitrile | – | – | 8 | – | – | – |
Phosphate buffer | – | – | 0 | – | – | – |
Ethanol | – | – | – | 6 | 6 | – |
Instruments | Â | Â | Â | Â | Â | Â |
Spectrophotometer/ /HPLC | Â | Â | Â | Â | Â | Â |
Energy | 0 [≤ 0.1 kWh/sample] | 0 [≤ 0.1 kWh/sample] | 1 [> 0.1 kWh/sample] | 0 [≤ 0.1 kWh/sample] | 0 [≤ 0.1 kWh/sample] | 0 [≤ 0.1 kWh/sample] |
Occupational hazard | 0 | 0 | 0 | 0 | 0 | 0 |
Waste | 3 | 3 | 6 | 3 | 3 | 3 |
Total penalty points | Σ 3 | Σ 9 | Σ 27 | Σ 9 | Σ 9 | Σ 3 |
Analytical eco-scale total score | 97 | 91 | 73 | 91 | 91 | 97 |
Analytical eco-scale total scorea,b | Excellent green analysis | Excellent green analysis | Acceptable green analysis | Excellent green analysis | Excellent green analysis | Excellent green analysis |
GAPI pentagram |
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