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Table 9 Important toxicity predication of compounds 4a, 7a, 7b, 7c, 9c, 15b, 16a, 16b and 16c

From: Synthesis, anticancer evaluation, molecular docking and ADME study of novel pyrido[4ʹ,3ʹ:3,4]pyrazolo[1,5-a]pyrimidines as potential tropomyosin receptor kinase A (TrKA) inhibitors

Compd. no

Mutag

Tum

Irr

Repd

Drug likeness

Drug Score

4a

No

No

No

No

6.35

0.98

7a

No

No

No

No

5.04

0.94

7b

No

No

No

high

6.26

0.55

7c

No

No

No

No

6.77

0.91

9c

No

medium

No

high

5.44

0.43

15b

No

No

No

high

6.27

0.55

16a

No

high

No

high

5.56

0.33

16b

No

No

No

high

5.41

0.54

16c

No

medium

No

high

5,46

0.43

  1. Mutag Mutagenicity, Tum Tumorigenicity, Irr Irritating effects, Repd Reproductive effects