Synthesis, anticancer evaluation, molecular docking and ADME study of novel pyrido[4ʹ,3ʹ:3,4]pyrazolo[1,5-a]pyrimidines as potential tropomyosin receptor kinase A (TrKA) inhibitors

Table 4 Inhibitory activity of compounds 7b, 9c, 15b, 16a and 16c against tropomyosin receptor kinase A in vitro using kinase assay technique

Compound no	Tropomyosin receptor kinase A IC₅₀ (μg/ml)
7b	0.064 ± 0.0037
9c	0.158 ± 0.0092
15b	0.101 ± 0.0059
16a	0.072 ± 0.0042
16c	0.047 ± 0.0027
Larotrectinib	0.034 ± 0.0021

ISSN: 2661-801X