Fig. 2

(A): P. falciparum PPI network. This network consists of 56 nodes and 82 edges with an average node degree of 1.05. The top-interacting nodes are colored red (32.1%, 18 proteins of all interacting nodes, i.e., hub protein). The selection criterion for the top-interacting proteins was a minimum of five interactions for each protein. (B): The top interacting nodes (i.e., hub nodes arranged by their degree value). Blue arrows represent the proteins predicted as probable targets for compound 2 (limonin) investigated in the presented study. The thickness of the lines (i.e., edges) represents the degree of confidence (i.e., the strength of data support)