Table 9 Stability of the six drugs in spiked human plasma
Drug | concentrations in plasma (µg/mL) | Long term % dev ±%RSD | Benchtop % dev ±%RSD | Auto-sampler % dev ±%RSD | Freeze and thaw % dev ± %RSD | |
|---|---|---|---|---|---|---|
IMP | QCL | 30.0 | -7.36 ± 1.36 | -2.35 ± 1.40 | -1.13 ± 0.81 | -3.91 ± 0.22 |
QCM | 40.0 | -7.18 ± 1.51 | -1.72 ± 1.40 | -1.28 ± 1.17 | -4.24 ± 1.48 | |
QCH | 75.0 | -6.88 ± 0.39 | -2.79 ± 0.69 | -1.56 ± 0.66 | -4.55 ± 1.02 | |
ETP | QCL | 50.0 | -7.34 ± 0.60 | -2.73 ± 0.66 | -1.87 ± 1.65 | -4.88 ± 0.65 |
QCM | 140.0 | -6.41 ± 0.63 | -2.59 ± 0.80 | -1.08 ± 0.16 | -3.14 ± 0.10 | |
QCH | 280.0 | -7.86 ± 0.07 | -1.94 ± 0.11 | -1.26 ± 0.33 | -3.18 ± 0.15 | |
CLS | QCL | 30.0 | -6.76 ± 0.46 | -1.80 ± 1.26 | -1.27 ± 1.17 | -4.28 ± 0.16 |
QCM | 40.0 | -5.64 ± 0.66 | -1.80 ± 0.48 | -1.21 ± 1.06 | -3.39 ± 0.46 | |
QCH | 75.0 | -6.21 ± 0.33 | -2.96 ± 1.15 | -1.91 ± 0.71 | -4.20 ± 1.17 | |
MRP | QCL | 15.0 | -5.85 ± 0.71 | -2.57 ± 0.25 | -1.68 ± 0.41 | -3.13 ± 1.06 |
QCM | 35.0 | -6.64 ± 1.19 | -1.65 ± 1.04 | -0.17 ± 0.11 | -4.39 ± 0.55 | |
QCH | 75.0 | -5.36 ± 1.24 | -3.60 ± 0.30 | -2.94 ± 0.62 | -4.39 ± 0.95 | |
PRB | QCL | 15.0 | -6.98 ± 0.51 | -2.49 ± 1.13 | -1.62 ± 0.19 | -4.16 ± 1.21 |
QCM | 35.0 | -7.02 ± 1.06 | -1.91 ± 1.76 | -1.57 ± 0.72 | -3.67 ± 0.80 | |
QCH | 75.0 | -4.79 ± 0.27 | -2.15 ± 1.18 | -0.57 ± 0.14 | -3.12 ± 0.49 | |
WRF | QCL | 6.0 | -6.89 ± 0.15 | -2.12 ± 0.50 | -1.26 ± 0.48 | -3.94 ± 0.22 |
QCM | 12.0 | -5.33 ± 0.14 | -1.02 ± 0.76 | -0.94 ± 0.89 | -3.18 ± 0.55 | |
QCH | 25.0 | -4.11 ± 1.09 | -1.83 ± 1.18 | -0.90 ± 0.78 | -2.78 ± 1.00 | |