Drugs | Concentrations in plasma (µg/mL) | Within run (n = 3) | Between run (n = 12) | |||
Mean accuracy (%R*) | Precision (%RSD**) | Mean accuracy (%R) | Precision (%RSD) | |||
IMP | LLOQ | 10.0 | 99.73 | 1.22 | 98.56 | 1.55 |
QCL | 30.0 | 99.03 | 0.68 | 98.45 | 1.08 | |
QCM | 40.0 | 100.37 | 0.21 | 99.52 | 1.19 | |
QCH | 75.0 | 99.94 | 0.77 | 99.24 | 0.66 | |
ETP | LLOQ | 15.0 | 99.09 | 0.69 | 98.75 | 0.33 |
QCL | 50.0 | 100.83 | 0.44 | 99.43 | 1.17 | |
QCM | 140.0 | 99.79 | 0.28 | 98.64 | 0.99 | |
QCH | 280.0 | 99.92 | 0.64 | 99.08 | 0.92 | |
CLS | LLOQ | 10.0 | 100.52 | 0.33 | 99.05 | 0.96 |
QCL | 30.0 | 99.35 | 0.86 | 98.63 | 0.81 | |
QCM | 40.0 | 99.45 | 0.50 | 98.95 | 1.08 | |
QCH | 75.0 | 100.28 | 0.55 | 99.15 | 0.93 | |
MRP | LLOQ | 5.0 | 99.19 | 1.88 | 98.37 | 0.22 |
QCL | 15.0 | 99.60 | 0.70 | 97.91 | 0.99 | |
QCM | 35.0 | 99.69 | 0.68 | 99.17 | 0.44 | |
QCH | 75.0 | 100.50 | 0.46 | 98.84 | 1.25 | |
PRB | LLOQ | 5.0 | 99.32 | 0.81 | 98.32 | 0.76 |
QCL | 15.0 | 99.72 | 0.40 | 98.27 | 1.37 | |
QCM | 35.0 | 99.90 | 0.65 | 98.17 | 1.62 | |
QCH | 75.0 | 100.04 | 0.60 | 98.35 | 1.50 | |
WRF | LLOQ | 1.0 | 98.56 | 0.19 | 97.72 | 0.63 |
QCL | 6.0 | 99.61 | 0.97 | 98.15 | 1.23 | |
QCM | 12.0 | 98.14 | 0.31 | 97.26 | 0.83 | |
QCH | 25.0 | 99.72 | 0.78 | 99.18 | 0.66 |