Table 6 Linearity and LLOQ of the six drugs in spiked human plasma
Drug | Linearity (µg/mL) | Regression equation | R2* | LLOQ (µg/mL) |
|---|---|---|---|---|
IMP | 10.0–100.0 | y = 0.1254x − 0.2991 | 0.9998 | 10.0 |
ETP | 15.0 – 400.0 | y = 0.2483x + 1.3255 | 0.9998 | 15.0 |
MRP | 5.0–100.0 | y = 0.1396x + 1.6883 | 0.9998 | 5.0 |
CLS | 10.0–100.0 | y = 0.1246x + 0.7331 | 0.9999 | 10.0 |
PRB | 5.0–100.0 | y = 0.2483x + 0.3202 | 0.9999 | 5.0 |
WRF | 1.0–30.0 | y = 0.5596x − 0.18 | 0.9998 | 1.0 |