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Table 7 Comparison of reaction effects of 6 acetophenone derivatives with pyridine hydrobromide

From: Application of α-bromination reaction on acetophenone derivatives in experimental teaching: a chemical innovation experiment engaging junior undergraduates

Acetophenone Derivatives

Yield

By-product

Cost

4-(Trifluoromethyl)acetophenone

90%

Less

Expensive

4-(Trifluoromethoxy)acetophenone

88%

More

Expensive

4-Chloroacetophenone

85%

Less

Cheap

4-Bromoacetophenone,

78%

More

Cheap

4-Iodoacetophenone

66%

More

Cheap

4-Phenylacetophenone

70%

More

Cheap