Table 4 The main pharmacokinetic parameters of abexinostat in rat plasma after intragastric administration of abexinostat at a single dose of 8.00 mg/kg
Parameter | Abexinostat |
|---|---|
AUC0-t (ng/mL*h) | 460.57 ± 38.89 |
AUC0-∞ (ng/mL*h) | 501.25 ± 40.15 |
MRT0-t (h) | 14.76 ± 0.80 |
MRT0-∞ (h) | 19.14 ± 2.55 |
t1/2 (h) | 13.80 ± 2.50 |
Tmax (h) | 1.39 ± 1.29 |
CLz/F (L/h/kg) | 16.04 ± 1.26 |
Cmax (ng/mL) | 28.20 ± 7.67 |