Table 1 Biological details of the selected receptor proteins
From: Computational design of anti-cancer peptides tailored to target specific tumor markers
Targets | Cellular location | Type | Regulates | Regulated by | Signaling pathways | Natural Ligands |
|---|---|---|---|---|---|---|
CXCR1 | Cell membrane | Receptor | Ca2 +  Erk1/2 CCR5 CXCR4 | IL8 TNF Lipopoly- saccharides | IL8 Signaling Agranulocytes adhesion | IL8 CXCL6 |
OPG | Extracellular space | Decoy Receptor Secreted | RANKL RANK Ca+2 TRAIL DR4 | IL1 RANKL TNF | NF-KB Signaling IL-6 Signaling | RANKL TRAIL APRIL RUNX2 |
DcR3 | Extracellular space | Decoy Receptor Secreted | IL6, IL10, IL2, IFNG | VEGF MTOR | PI3K/AKT/GSK-3beta/beta-catenin signaling pathway | FASLG TNFSF14 TNFSF15 PPP1R7 |