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Table 3 Statistical analysis of the results obtained by the developed spectrophotometric methods and official and reported methods for determination of ASP and ROX in their pure powdered form

From: Spectrophotometric resolution for quantitative analysis of aspirin and rivaroxaban combination therapy in biological fluids using simple and eco-friendly procedure

Parameter

ASP

ROX

DW

RD

1DD

Officiala

DW

RD

1DD

Reported b

Mean

100.26

100.11

99.7

100.22

100.06

100.24

99.67

100.48

SD

1.00

1.05

0.89

0.95

0.97

0.68

0.706

0.92

n

10

10

10

6

8

8

8

6

Variance

1.00

1.11

0.79

0.90

0.94

0.47

0.49

0.84

Student’s t-test

0.078 (2.145)*

0.205 (2.145)*

1.215 (2.145)*

 

0.855 (2.179)*

0.562 (2.179)*

1.888 (2.179)*

 

F

1.10 (4.77)*

1.23 (4.77)*

1.14 (4.77)*

 

1.11 (4.88)*

1.79 (4.88)*

3.81 (4.88)*

 
  1. *The figures in parenthesis are the corresponding theoretical values at P = 0.05
  2. aOfficial titrimetric USP method
  3. bReported HPLC method using C18 column isocratic elution using ACN: H2O (55:45 V/V), UV detection at 249 nm