Skip to main content

Table 9 DPPH Scavenging activity of 5,6,7,8-tetrahydrothieno[2,3-c]isoquinolines 1, 3, 6 and 7a–e, and 6,7,8,9-tetrahydrothieno[2,3-c]isoquinolines 8a, b

From: Novel tetrahydroisoquinolines as DHFR and CDK2 inhibitors: synthesis, characterization, anticancer activity and antioxidant properties

Compound no.

0.01 µg/mL inhibition (%)

0.05 µg/mL inhibition (%)

1

61.01 ± 0.58

92.3 ± 0.44

3

25.58 ± 2.20

81.39 ± 3.87

6

69.67 ± 5.65

83.72 ± 4.08

7a

43.26 ± 0.73

62.96 ± 0.73

7b

48.59 ± 0.73

52.19 ± 0.58

7c

77.90 ± 6.22

81.39 ± 4.99

7d

48.08 ± 0.87

69.73 ± 0.73

7e

44.28 ± 0.44

47.36 ± 0.44

8a

14.22 ± 1.32

23.66 ± 2.12

8e

80.45 ± 5.22

89.67 ± 4.76

Vitamin C

50.54 ± 2.76

69.90 ± 3.98

  1. *These data are represented by Mean ± SD. DPPH scavenging activity represented as %. Statistical analysis is carried out using two-way ANOVA coupled with a CO-state computer. The ascorbic acid standard was used as a positive control. DPPH scavenging activity was calculated as follows: % Inhibition = 100 − [Absorbance of the test compound/Absorbance of the control] × 100
  2. The important of the information in the asterisk : to inform the software (ANOVA) used in this study and the equation used for calculation the results
Back to article page

BMC Chemistry

ISSN: 2661-801X

Contact us