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Table 8 Enzyme inhibitory activity of compounds 7e and 8d

From: Novel tetrahydroisoquinolines as DHFR and CDK2 inhibitors: synthesis, characterization, anticancer activity and antioxidant properties

RET tyrosine kinase (IC50 ± SD; µM)

Eef2 kinase (IC50 ± SD; µM)

IKB kinase B (IC50 ± SD; µM)

Compound 7e

Control (staurosporine)

Compound 8d

Control (NH125)

Compound 8d

Control (TPCA-1)

0.106 ± 0.005

0.069 ± 0.003

0.689 ± 0.036

0.357 ± 0.0190

0.240 ± 0.013

0.072 ± 0.004

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BMC Chemistry

ISSN: 2661-801X

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