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Table 7 DHFR inhibitory activity of the compound 8d

From: Novel tetrahydroisoquinolines as DHFR and CDK2 inhibitors: synthesis, characterization, anticancer activity and antioxidant properties

Compd. no.

M.W. (g/mol)

DHFR inhibition (IC50 ± SD; µM)

8d

670

0.199 ± 0.016

Methotrexate

454.44

0.131 ± 0.007

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BMC Chemistry

ISSN: 2661-801X

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