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Table 4 Robustness of the proposed spectroscopic methods for the determination of ALC and OLO

From: Determination of antihistaminic drugs alcaftadine and olopatadine hydrochloride via ion-pairing with eosin Y as a spectrofluorimetric and spectrophotometric probe: application to dosage forms

Parameter

 

% Recovery ± SDa

  

Method Ab

Method B b

Method Cb

Method Db

Buffer pH

− 0.1

100.16 ± 1.25

99.61 ± 0.69

99.75 ± 0.22

98.38 ± 1.13

 

 + 0.1

99.68 ± 1.31

99.79 ± 0.57

100.26 ± 0.45

98.65 ± 1.47

Buffer volume

− 0.1 mL

99.03 ± 0.56

99.15 ± 0.27

100.18 ± 0.65

98.85 ± 1.11

 

 + 0.1 mL

99.51 ± 0.49

99.52 ± 0.84

99.89 ± 0.25

100.20 ± 0.77

Eosin volume

− 0.1 mL

98.23 ± 0.33

99.43 ± 0.72

99.17 ± 1. 09

98.17 ± 0.91

 

 + 0.1ML

100.62 ± 1.07

100.16 ± 1.04

100.04 ± 1.52

98.44 ± 1.57

  1. aThe values are the mean of three determinations
  2. bDrug concentration is 1500 ng mL−1 in method A, 4.0 μg mL−1 in method B, 1200 ng mL−1 in method C and 6.0 μg mL−1 in method D
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BMC Chemistry

ISSN: 2661-801X

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