Skip to main content

Table 3 A mitotic inhibitor, anticancer activity assessment using PASS online software

From: New thiazole, thiophene and 2-pyridone compounds incorporating dimethylaniline moiety: synthesis, cytotoxicity, ADME and molecular docking studies

Compound no.

Antimitotic

Antineoplastic (non-small cell lung cancer)

Insulysin inhibitor

Pa

Pi

Pa

Pi

Pa

Pi

1

NA

NA

0.225

0.054

0.683

0.011

2

0.595

0.005

0.203

0.076

0.680

0.011

3

0.392

0.014

NA

NA

0.675

0.012

4

NA

NA

NA

NA

0.751

0.004

5

0.216

0.048

NA

NA

0.427

0.076

6

0.454

0.010

0.153

0.153

0.428

0.076

7

0.195

0.060

0.175

0.114

0.397

0.089

8a

NA

NA

0.197

0.083

0.874

0.003

8b

0.145

0.092

0.241

0.043

0.832

0.003

8c

NA

NA

0.170

0.122

0.820

0.003

8d

NA

NA

0.160

0.140

0.829

0.003

8e

NA

NA

0.200

0.079

0.805

0.003

8f

NA

NA

NA

NA

0.788

0.004

9a

NA

NA

NA

NA

0.292

0.145

9b

NA

NA

0.298

0.024

0.239

0.201

9c

NA

NA

0.234

0.048

NA

NA

9d

NA

NA

0.207

0.071

0.263

0.173

9e

NA

NA

0.238

0.045

0.226

0.219

9f

NA

NA

0.193

0.088

NA

NA