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Table 4 IC50 (µM) values of compound 8u on VEGFR-2, FGFR-1 and BRAF in reference to sorafenib (I)

From: Receptor-based pharmacophore modeling, molecular docking, synthesis and biological evaluation of novel VEGFR-2, FGFR-1, and BRAF multi-kinase inhibitors

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IC50 (µM)

 

VEGFR-2

FGFR-1

BRAF

8u

0.93 ± 0.10

3.74 ± 0.34

0.25 ± 0.03

Sorafenib

0.10 ± 0.01

0.58 ± 0.10 [62]

0.02 ± 0.002

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BMC Chemistry

ISSN: 2661-801X

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