Receptor-based pharmacophore modeling, molecular docking, synthesis and biological evaluation of novel VEGFR-2, FGFR-1, and BRAF multi-kinase inhibitors

Table 2 The collective assessment metrics of the generated pharmacophore models

Ph4 no.	Se	Sp	Ya	E	Acc	DR	F1	MCC
Ph4-1	0.753	0.955	0.344	11.240	0.948	0.789	0.4721	0.4875
Ph4-2	0.753	0.958	0.362	11.832	0.952	0.786	0.4889	0.5017
Ph4-3	0.753	0.959	0.369	12.070	0.953	0.785	0.4955	0.5073
Ph4-4	0.753	0.961	0.377	12.318	0.954	0.784	0.5023	0.5131
Ph4-5	0.740	0.962	0.383	12.523	0.956	0.769	0.5047	0.5128
Ph4-6	0.726	0.964	0.387	12.650	0.956	0.753	0.5048	0.5106
Ph4-7	0.753	0.942	0.289	9.465	0.936	0.800	0.4183	0.4422
Ph4-8	0.753	0.935	0.267	8.730	0.929	0.806	0.3943	0.4220
Ph4-9	0.767	0.919	0.230	7.535	0.915	0.835	0.3544	0.3908
Ph4-10	0.767	0.936	0.273	8.932	0.930	0.820	0.4029	0.4318
Ph4-11	0.767	0.924	0.242	7.927	0.920	0.830	0.3684	0.4027
Ph4-12	0.808	0.905	0.211	6.915	0.902	0.893	0.3352	0.3822
Ph4-13	0.849	0.773	0.105	3.448	0.775	1.099	0.1876	0.2486
Ph4-14	0.849	0.824	0.132	4.323	0.825	1.031	0.2288	0.2918
Ph4-15	0.849	0.861	0.161	5.279	0.860	0.987	0.2713	0.3328
Ph4-16	0.479	0.952	0.240	7.839	0.938	0.504	0.3196	0.3100
Ph4-17	0.425	0.986	0.484	15.838	0.969	0.431	0.4526	0.4375

(Metric’s values of the best performing pharmacophore model (Ph4-4) are shown in bold)

ISSN: 2661-801X