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Table 9 Greenness of the suggested technique and other reported methods

From: Eco-friendly, sensitive and inventive first derivative synchronous spectrofluorimetric determination of ciprofloxacin and phenylephrine in their pure form, single and combined eye drops

 

Proposed method

Reported spectrophotometric method [36]

Reported HPLC method [37]

GAPI

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NEMI

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AGREE

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Eco-Scale

Item Penalty points

1-Reagent Water 0

2-Spectrofluorimeter 0

3-Occupational hazard 0

4-Waste 3

Total penalty points 3

Eco- Scale score 97

Item Penalty points

1-Reagent NaOH 1

2-UV- Vis Spectrometer 0

3-Occupational hazard 0

4-Waste 3

Total penalty points 4

Eco- Scale score 96

Item Penalty points

1-Reagent Methanol 12

Acetonitrille 8

Phosphate buffer 0

2-HPLC–UV 1

3-Occupational hazard 0

4-Waste 3 Total penalty points 24 Eco- Scale score 76