Discovery of dual kinase inhibitors targeting VEGFR2 and FAK: structure-based pharmacophore modeling, virtual screening, and molecular docking studies

Table 5 Hit filtration criteria

Criterion	Cutoff
Lipinski’s rule violation count	≤ 1
Molecular weight	< 500
logP	≤ 5
# HBA	≤ 10
# HBD	≤ 5
Veber’s rule
Number of rotatable bonds	≤ 10
Polar surface area	< 140 Å²
LogS	≥ − 5

ISSN: 2661-801X