Discovery of dual kinase inhibitors targeting VEGFR2 and FAK: structure-based pharmacophore modeling, virtual screening, and molecular docking studies

Table 1 VEGFR2 PDB structures used in training set generation

#	PDB ID	Ref	IC₅₀ (nM)
VEGFR_1	4ASE	[60]	0.04
VEGFR_2	4ASD	[60]	2.3
VEGFR_3	2QU6	[67]	15
VEGFR_4	3VHE	[68]	6.2
VEGFR_5	3EWH	[69]	69 ± 10
VEGFR_6	3VNT	[70]	2.2
VEGFR_7	3WZD	[47]	5.1
VEGFR_8	6XVK	[71]	0.538

ISSN: 2661-801X