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Table 4 Bacterial counts (CFU/g) of a mouse skin abrasion lesion on the 4th, 9th, and 14th days after treatment

From: Vancomycin and nisin-modified magnetic Fe3O4@SiO2 nanostructures coated with chitosan to enhance antibacterial efficiency against methicillin resistant Staphylococcus aureus (MRSA) infection in a murine superficial wound model

Day

MRSA

Free vancomycin

Fe3O4@SiO2@CS

Fe3O4@SiO2@CS-VANCO

Free nisin

Fe3O4@SiO2@CS-NISIN

0

3 × 107

5.4 × 107

5.5 × 107

5.4 × 107

5.4 × 107

5.4 × 107

4

3 × 107

4.6 × 106 ± 1.8 × 106

5.4 × 107 ± 1.7 × 107

3.6 × 105 ± 2.2 × 105

5.2 × 106 ± 1.7 × 106

4.3 × 107 ± 0.4 × 107

9

3 × 107

5.7 × 104 ± 0.8 × 104

3.7 × 105 ± 1.4 × 105

6 × 103 ± 1.5 × 103

6.2 × 104 ± 0.9 × 104

1.4 × 105 ± 0.3 × 105

14

3 × 107

178 ± 15

315 ± 51

108 ± 12

210 ± 23

280 ± 23

  1. MRSA methicillin-resistant Staphylococcus aureus, CS chitosan, VANCO vancomycin