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Table 8 Quantification outcome of CI, and OR via the suggested tools in tablet formulation and enriched serum

From: The effectiveness of multivariate and univariate spectrophotometric techniques for the concurrent estimation of ornidazole and ciprofloxacin HCl in tablet formulation and spiked serum: estimating greenness and whiteness profile

Tablet formulation

Tool

ANN

FSD

MC

Drug

CI

OR

CI

OR

CI

OR

Dosage/Tab μg/ml

500

500

500

500

500

500

Assay μg/mla

500.75

500.15

501.25

500.20

496.55

496.95

Recovery% ± SD

100.15 ± 1.67

100.03 ± 1.78

100.25 ± 1.04

100.04 ± 1.15

99.31 ± 1.66

99.39 ± 1.81

Standard addition b.c

99.40 ± 1.88

99.74 ± 1.82

99.98 ± 1.59

99.85 ± 0.24

9.60 ± 0.78

99.65 ± 0.22

Serum sample

Tool

ANN

FSD

MC

Drugs ratio(μg/ml) CI: OR

CI

OR

CI

OR

CI

OR

2.6:10.5d

98.52 ± 0.85

97.9 ± 1.19

95.37 ± 1.10

98.00 ± 0.33

96.41 ± 1.04

97.39 ± 0.39

10:5

96.42 ± 0.69

95.82 ± 1.50

95.50 ± 0.69

97.40 ± 1.52

95.57 ± 0.68

96.73 ± 1.41

5:15

100.30 ± 1.04

100.26 ± 1.12

96.78 ± 1.04

98.13 ± 0.50

96.13 ± 1.50

97.90 ± 0.14

  1. aAverage μg/ml for the 3 repetitions of CI and OR
  2. bThe standard addition is(4,5, 6 μg/ml) for CIPH and ORNI
  3. cThe computed value is the average % ± SD for 3 concentrations of the standard added with 3 repetitions
  4. dRecovery% ± SD for the 3 repetitions of CI and OR
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BMC Chemistry

ISSN: 2661-801X

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