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Table 4 The strengths points and limitations of the elaborated Tools

From: The effectiveness of multivariate and univariate spectrophotometric techniques for the concurrent estimation of ornidazole and ciprofloxacin HCl in tablet formulation and spiked serum: estimating greenness and whiteness profile

Tool

Benefits

Limitations

ANN

• Eliminates the error reverting to employing a single wavelength regression such as in univariate UV approaches

• Does not demand a monotonous validation process

• Can be trained on diverse ratios of mixes

• Needs many tests to obtain accurate prediction outcomes, which needs to adjust many parameters like transfer functions, layers, neuron number, goal, and the learning rate

• The improper adjustment of one of the previous parameters may lead to learning errors or the occurrence of overfitting issues

FSD

• Enhances the overlaid spectra resolution

• Does not impact the signal/noise ratio

• Doesn’t require a special program or (cos, sin) transformation for performing like in Discrete Fourier Transform

• Crucial measurements of the signals at the selected wavelength

• Influenced by the increment of wavelength

MC

• The mean-centered signals are measured at the maximum points, for higher sensitivity

• Does not impact the signal/noise ratio

• The computed arithmetic mean is greatly affected by skewed data

• Needs to test the best divisor concentration and the best wavelength range for the mean centering process