Chromatographic analysis of triple cough therapy; bromhexine, guaiafenesin and salbutamol and pharmaceutical impurity: in-silico toxicity profile of drug impurity

Table 5 Results of robustness of the developed methods

Analyte		TLC-densitometric method		HPLC method
Analyte		Triethylamine ratio ± 0.1mL	Mobile phase saturation time ± 5 min	Methanol ratio ± 2%	Wavelength ± 2 nm
GUF	%RSD^a	0.11	0.11	0.09	0.05
BR		0.01	0.01	0.03	0.05
SAL		0.65	0.43	0.07	0.03
GUL		0.04	0.01	0.07	0.04

a%RSD of the change in Rf value (for TLC-densitometric method) and the change in tR value (for HPLC method) values on changing some conditions

ISSN: 2661-801X