Table 2 In vitro anti-proliferative effects (IC50, µM) of compounds 8a-l against A549, MDA-MB231 and MCF7 cell lines
Compound | R | A549 | MDA-MB231 | MCF7 |
|---|---|---|---|---|
8a | H | > 50 | > 50 | > 50 |
8b | 3-CH3 | > 50 | > 50 | 29 ± 0.005 |
8c | 4-CH3 | > 50 | > 50 | 25 ± 0.001 |
8d | 3-OCH3 | > 50 | > 50 | > 50 |
8e | 4-OCH3 | > 50 | > 50 | > 50 |
8f | 3-F | > 50 | > 50 | > 50 |
8g | 3-Cl | > 50 | > 50 | 39.1 ± 0.001 |
8h | 4-Cl | > 50 | > 50 | > 50 |
8i | 4-Br | > 50 | > 50 | > 50 |
8j | 3,4DiCl | > 50 | > 50 | > 50 |
8k | 3-Cl-4-CH3 | > 50 | 46 ± 0.003 | > 50 |
8l | 4-Cl-3-CF3 | > 50 | > 50 | > 50 |
Etoposide | – | 25.8 ± 0.0008 | 27.9 ± 0.002 | 29.8 ± 0.0007 |