Simultaneous determination of 14 analgesics in postoperative analgesic solution by HPLC–DAD and LC–MS/MS

BMC Chemistry

Table 1 Q1/Q3 masses and compound-specific parameters for both MRM transitions of each analyte

Analyte name w/MRM #	Retention time (t_R)	Molecular formula	Elative molecular mass	Q1 Mass	Q3 Mass	DP	CE
Morphine	1.02	C₁₇H₂₀CLNO₃	285.30	286.1	153.1	100	53
					201.0*	100	36
Hydromorphone	1.44	C₁₇H₁₉NO₃	285.34	286.0	199.1	100	40
					185.0*	100	40
Oxycodone	2.43	C_l8H₂₁NO₄	315.33	316.2	256.1	80	36
					241.1*	80	36
Ketamine	3.44	C₁₃H₁₇CL₂NO	237.69	238.1	179.0	28	18
					125.0*	28	25
Tramadol	4.57	C₁₆H₂₆CLNO₂	263.34	264.2	159.0	50	37
					58.0*	50	37
Dezocine	4.9	C₁₆H₂₃NO	245.36	246.2	147.1	80	28
					229.1*	80	14
Ropivacaine	5.66	C₁₇H₂₆N₂O	274.36	275.3	84.0	100	40
					126.2*	100	40
Remifentanil	6.97	C₂₀H₂₈N₂O₅	376.45	377.2	113.1	65	38
					317.2*	65	22
Butorphanol	7.17	C₂₁H₂₉NO₂	327.46	328.0	282.0	100	40
					242.0*	100	40
Bupivacaine	7.37	C₁₈H₂₈N₂O	288.39	289.3	84.1	40	51
					140.2*	40	29
Droperidol	7.59	C₂₂H₂₂FN₃O₂	379.43	380.1	194.0	100	40
					165.0*	100	47
Fentanyl	7.87	C₂₂H₂₈N₂O	336.47	337.0	105.0	70	31
					188.0*	70	25
Lornoxicam	9.29	C₁₃H₁₀CLN₃O₄S₂	371.82	372.0	164.0	100	40
					121.0*	100	40
Sufentanil	9.61	C₂₂H₃₀N₂O₂S	386.55	387.3	111.2	50	55
					238.1*	50	27

ISSN: 2661-801X