Table 4 The plasma drug concentration of colistin sulfate and tigecyclin
No. | Gender | BMI (kg/m2) | CrCLa (ml/min) | ALBb (g/L) | Colistin sulfate dosage of administration | Colistin sulfate | Tigecycline dosage of administration | Tigecycline | ||
|---|---|---|---|---|---|---|---|---|---|---|
Trough concentration(µg/mL) | Peak concentration(µg/mL) | Trough concentration(µg/mL) | Peak concentration(µg/mL) | |||||||
1 | Male | 27.04 | 107 | 33.8 | 500,000IU q12h | 0.26 | 1.13 | First dose 100 mg maintenance dose 50 mg q12h | 0.79 | 1.72 |
2 | Female | 27.69 | 36 | 30.35 | First dose 1 million IU maintenance dose 500,000 IU q12h | 2.02 | 4.56 | First dose 100 mg maintenance dose 50 mg q12h | 0.81 | 1.68 |
3 | Male | 23.88 | 90 | 26.80 | 500,000 IU q12h | 0.28 | 1.22 | First dose 100 mg maintenance dose 50 mg q12h | 0.77 | 1.67 |
4 | Male | 18.72 | 111 | 32.50 | 500,000 IU q12h | 0.28 | 1.39 | First dose 100 mg maintenance dose 50 mg q12h | 0.69 | 1.47 |
5 | Male | 22.14 | 84 | 28.00 | 500,000 IU q12h | 0.84 | 2.51 | First dose 100 mg maintenance dose 50 mg q12h | 0.58 | 1.17 |
6 | Femaee | 19.3 | 161 | 35.3 | 500,000 IU q12h | 0.15 | 0.89 | First dose 100 mg maintenance dose 50 mg q12h | 0.66 | 1.11 |
7 | Male | 24.16 | 59 | 36.72 | 500,000 IU q12h | 0.78 | 2.33 | First dose 100 mg maintenance dose 50 mg q12h | 0.58 | 1.01 |
8 | Male | 27.44 | 98 | 33.30 | 500,000 IU q12h | 0.39 | 1.93 | First dose 100 mg maintenance dose 50 mg q12h | 0.63 | 0.92 |
9 | Female | 20.91 | 106 | 32.71 | 500,000 IU q12h | 0.44 | 2.27 | First dose 100 mg maintenance dose 50 mg q12h | 0.65 | 1.22 |
10 | Female | 21.95 | 129 | 31.89 | 500,000 IU q12h | 0.37 | 2.03 | First dose 100 mg maintenance dose 50 mg q12h | 0.33 | 1.08 |
11 | Male | 22.51 | 27 | 27.10 | First dose 1 million IU maintenance dose 500,000 IU q12h | 2.51 | 4.27 | First dose 100 mg maintenance dose 50 mg q12h | 0.25 | 0.99 |
12 | Female | 23.71 | 170 | 32.50 | 500,000 IU q12h | 0.17 | 1.09 | First dose 100 mg maintenance dose 50 mg q12h | 0.48 | 1.78 |