From: Development of a practical synthesis of etravirine via a microwave-promoted amination
Solvent | Methoda | Temperature (°C) | Time | Pressure (psi) | Yield % |
---|---|---|---|---|---|
Dioxane | A | 120 | 12 h | – | 83.5 |
CH3CN | A | 120 | 12 h | – | 82.7 |
NMP | A | 120 | 12 h | – | 83.6 |
Dioxane | B | 120 | 30 min | 130 | 0 |
CH3CN | B | 120 | 30 min | 130 | 0 |
THF | B | 120 | 30 min | 130 | 0 |
DMF | B | 120 | 30 min | 128 | 67.7 |
DMSO | B | 120 | 30 min | 127 | 72.1 |
NMP | B | 120 | 30 min | 127 | 81.4 |