Design, synthesis, in silico and in vitro antimicrobial screenings of novel 1,2,4-triazoles carrying 1,2,3-triazole scaffold with lipophilic side chain tether

Table 1 Antimicrobial screening results of compounds 3–7(a–d) expressed as MIC defined as the least concentration that cause more than 80% growth inhibition of the microorganism (μg/mL)

Compound no.	Gram-positive organisms			Gram-negative organisms			Fungi
Compound no.	Bc	Ef	Sa	Pa	Ec	Pm	Ab	Ca
3a	256	512	512	128	256	512	512	256
3b	128	512	256	128	128	512	512	256
3c	64	256	128	64	128	256	256	128
3d	64	256	128	64	64	256	256	128
4a	128	256	128	64	128	256	256	128
4b	64	256	64	64	128	256	256	128
4c	64	128	64	32	64	128	64	64
4d	32	128	64	16	32	128	64	32
5a	32	128	64	32	64	256	128	64
5b	32	128	32	32	32	128	128	32
5c	16	64	32	16	32	64	32	16
5d	8	64	16	8	16	64	32	16
6a	16	64	32	16	16	128	32	8
6b	16	64	16	16	16	64	32	8
6c	4	32	8	8	8	32	16	4
6d	4	32	4	4	4	32	16	2
7a	8	32	16	8	8	64	16	4
7b	8	16	8	8	8	64	16	4
7c	2	16	4	4	4	32	8	2
7d	2	8	1	2	1	16	8	1
Ciprofloxacin	4	8	1	4	1	8	–	–
Fluconazole	–	–	–	–	–	–	4	1

Bacillus cereus ATTC 10876 (B. cereus), Enterococcus faecalis ATTC 29212 (E. faecalis), Staphylococcus aureus ATTC 25923 (S. aureus)
Proteus mirabilis ATTC 35659 (P. mirabilis), Escherichia coli ATTC 25922 (E. coli), Pseudomonas aeruginosa ATTC 27853 (P. aeruginosa)
Candida albicans ATTC 50193 (C. albicans), Aspergillus brasiliensis ATTC 16404 (A. brasiliensis)
MIC minimum inhibitory concentration

ISSN: 2661-801X