BMC Chemistry

Table 2 Determination of DRO, CAF, and PCT and PAP in laboratory prepared mixtures and pharmaceutical dosage forms by the proposed methods and results obtained by standard addition technique

From: Different applications of isosbestic points, normalized spectra and dual wavelength as powerful tools for resolution of multicomponent mixtures with severely overlapping spectra

Concentration (µg/mL)				Recovery%^a
Lab prepared mix.				DRO				CAF
DRO	CAF	PCT	PAP	D⁰	RD-Iso	IRD	DD-RD-DW	AAS	AAM	S¹DD	RD-Iso	IRD
2^b	3	20	2	101.24	98.78	100.95	101.25	99.46	100.35	100.27	100.22	100.27
10	10	10	1	98.24	99.75	99.33	98.24	99.65	100.17	99.98	99.97	99.98
6	12	6	6	99.42	99.41	99.87	99.42	99.94	100.43	100.23	100.22	100.24
20	8	4	4	100.13	100.05	99.96	100.14	99.62	100.18	100.00	99.98	100.01
12	20	8	2	99.83	99.82	99.84	99.84	99.78	100.22	100.00	100.01	100.00
0^c	2	10	1					99.97	99.97	100.19	101.20	100.15
0^d	2.6	20	2					100.07	99.89	100.21	99.67	100.20
Mean ± SD				99.77 ± 1.09	99.56 ± 0.49	99.99 ± 0.53	99.78 ± 1.09	99.78 ± 0.21	100.17 ± 0.19	100.12 ±0.12	100.20 ± 0.52	100.12 ± 0.12

Concentration (µg/mL)				Recovery%^a
Lab prepared mix.				PCT						PAP
DRO	CAF	PCT	PAP	AAS	AAM	S¹DD	RD-Iso	IRD	DD-RD-DW	D¹	DD-RD-DW
2^b	3	20	2	100.11	101.21	99.80	100.21	100.12	100.12	99.20	99.85
10	10	10	1	100.07	100.65	100.02	100.26	100.07	100.08	98.66	99.61
6	12	6	6	100.33	100.92	100.59	100.65	100.34	100.34	102.38	100.68
20	8	4	4	99.84	100.37	100.25	100.39	99.94	99.94	98.80	98.80
12	20	8	2	100.18	99.98	100.46	100.35	100.12	100.12	99.65	98.00
0^c	2	10	1	100.21	100.89	100.45	99.65	100.31	99.89	99.42	99.38
0^d	2.6	20	2	99.95	99.91	99.97	99.82	99.76	100.32	98.02	100.75
Mean ± SD				100.10 ± 0.16	100.56 ± 0.49	100.22 ± 0.29	100.19 ± 0.34	100.09 ± 0.20	100.11 ± 0.17	99.45 ± 1.40	99.57 ± 0.99

^aAverage of three determinations
^bThe ratio of the lab mixture in Petro tablets
^cThe ratio of the lab mixture of (CAF:PCT) in Soumadril Compound tablets
^dThe ratio of the lab mixture of (CAF:PCT) in Panadol Extra tablets

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