Table 1 Cytotoxic activity of the tested compounds against HepG2 
From: A facile synthesis and anticancer activity of some novel thiazoles carrying 1,3,4-thiadiazole moiety
Sample number | R | X | IC50 (μM) |
|---|---|---|---|
Doxorubicin | – | – | 0.72 ± 0.13 |
6a | Ac | H | 9.89 ± 0.19 |
6b | Ac | 4-Me | 39.06 ± 0.24 |
6c | Ac | 4-Cl | 1.29 ± 0.27 |
6d | Ac | 4-OMe | 64.35 ± 0.14 |
6e | Ac | 3-Cl | 4.03 ± 0.19 |
6f | Ac | 4-Br | 1.88 ± 0.08 |
6g | Ac | 2,4-Cl2 | 1.06 ± 0.12 |
12a | CO2Et | H | 4.70 ± 0.16 |
12b | CO2Et | 4-Me | 32.4 ± 0.19 |
12c | CO2Et | 4-Cl | 0.91 ± 0.20 |
12d | CO2Et | 2,4-Cl2 | 0.82 ± 0.13 |
18a | CONHPh | H | 6.79 ± 0.11 |
18b | CONHPh | 2,4-Cl2 | 1.25 ± 0.18 |