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Table 4 Thiol concentrations (×10−6 mol L−1) of different incubation media at hour 70 in the simulated colon condition

From: Colon targeted drug delivery of branch-chained disulphide cross-linked polymers: design, synthesis, and characterisation studies

Incubation medium

P10

P11

P12

P15

P21

P51

Bacteria only (1)

0.344 ± 0.076

0.151 ± 0.035

0.157 ± 0.007

0.299 ± 0.101

0.161 ± 0.019

0.146 ± 0.026

Polymer only (2)

2.509 ± 0.179

5.117 ± 0.537

8.212 ± 0.837

9.263 ± 0.151

3.791 ± 0.471

3.244 ± 0.357

Polymer + bacteria (3)

5.602 ± 0.159

20.288 ± 1.468

34.419 ± 0.541

56.898 ± 2.822

14.211 ± 0.675

7.915 ± 0.585

Statistical analysis

p < 0.05

p < 0.05

p < 0.05

p < 0.05

p < 0.05

p < 0.05

Dunnett (2-sided) (significant)

1 & 3

1 & 3

1 & 3

1 & 3

1 & 3

1 & 3

2 & 3

2 & 3

2 & 3

2 & 3

2 & 3

2 & 3

  1. Mean ± SD, N = 3. The incubation medium containing polymer + bacteria (3) is the control sample