Efficient synthesis and antimicrobial evaluation of some Mannich bases from 2-arylidine-1-thia-4-azaspiro[4.5]decan-3-ones

Table 5 Bactericidal activity of Mannich bases (6a-r) using Ciprofloxacin as standard antibacterial reference^a

Compound	*Staphylococcus aureus*	*Escherichia Coli*	*Pseudomonas aeroginosa*
6a	--	+	--
6b	++	+	++
6c	--	--	--
6d	++	+	+
6e	+++	+++	+++
6f	--	+	--
6g	+	++	--
6h	++	++	++++
6i	--	--	+
6j	++	--	--
6k	+	+++	++
6l	--	--	--
6m	+++	+++	++
6n	++++	++++	+++
6o	+	+	--
6p	++++	+	++
6q	++++	+++	+++
6r	-	++	+
Ciprofloxacin	++++	++++	++++

^a The activities are based on the diameter of zones of inhibition in mm. 50 μL of stock solution was applied in each hole of each paper disk. +: <15 mm; ++: 15–24 mm; +++: 25–34 mm; ++++: 35–44 mm.

ISSN: 2661-801X