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Table 2 Curative effect of the title compounds 5 against CMV in vivo a

From: Inorganic base-catalyzed formation of antivirally active N-substituted benzamides from α-amido sulfones and N-nucleophile

Agent

R1

R2

Curative effect (%)

5a

m-Cl

H

24.2

5b

m-Cl

o-F

35.1

5c

m-Cl

p-F

42.2

5d

m-Cl

o-Cl

30.6

5e

m-Cl

p-Cl

28.2

5f

m-Cl

o-OCH3

22.9

5g

m-Cl

p-CH3

27.5

5h

m-Cl

o-NO2

32.1

5i

m-Cl

p-NO2

38.5

5j

m-Cl

m-NO2

36.0

5k

H

p-CH3

27.8

5l

H

p-NO2

35.0

5m

H

p-F

36.0

5n

p-Cl

H

26.2

5o

p-Cl

o-F

48.7

5p

p-Cl

p-F

35.8

5q

p-Cl

p-CH3

36.4

5r

p-Cl

o-OCH3

40.5

5s

p-Cl

o-Cl

37.9

5t

p-Cl

p-Cl

30.2

5u

p-Cl

p-NO2

27.2

Ningnanmycin

  

53.4

  1. a All antiviral tests were carried out at the concentration of 500 μg/mL.