Anticholinesterase activities of novel isoindolin-1,3-dione-based acetohydrazide derivatives: design, synthesis, biological evaluation, molecular dynamic study

Table 2 AChE and BChE inhibitory activities of analogs 8a–h

Comp	R¹	R²	R³	AChE IC₅₀ (µM)	BChE IC₅₀ (µM)
8a	Methyl	H	2-oxypropyl-isoindolinedione	0.11 ± 0.05	30.2 ± 2.8
8b	Ethyl	H	2-oxypropyl-isoindolinedione	0.18 ± 0.01	26.8 ± 0.8
8c	Ethyl	5-NO₂	2-oxypropyl-isoindolinedione	0.16 ± 0.04	21.8 ± 1.3
8d	Ethyl	H	3-oxypropyl-isoindolinedione	0.16 ± 0.03	11.8 ± 0.5
8e	Ethyl	4-OCH₃	3-oxypropyl-isoindolinedione	0.21 ± 0.03	14.7 ± 0.2
8f	Methyl	H	4-oxypropyl-isoindolinedione	0.32 ± 0.02	15.7 ± 1.2
8g	Ethyl	H	4-oxypropyl-isoindolinedione	0.86 ± 0.02	5.7 ± 0.2
8h	Ethyl	3-OCH₃	4-oxypropyl-isoindolinedione	0.17 ± 0.06	13.2 ± 1.4
Donepezil^a	–	–	–	0.023 ± 0.02	7.2 ± 0.1

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