Green chemometric-assisted UV-spectrophotometric methods for the determination of favipiravir, cefixime and moxifloxacin hydrochloride as an effective therapeutic combination for COVID-19; application in pharmaceutical form and spiked human plasma

Table 8 Determination of FPV, CEF and MFX in pharmaceutical tablets by described model and statistical comparison with previous reported methods

Parameters	FPV			CEF			MFX
Parameters	PLS	GA-PLS	Reported method [10]	PLS	GA-PLS	Reported method [23]	PLS	GA-PLS	Reported method [23]
Number of measurements	5	5	5	5	5	5	5	5	5
Mean % Recovery	99.91	99.73	100.33	99.51	100.42	99.77	100.45	100.15	99.36
% RSD	1.398	0.947	0.907	1.653	1.261	1.007	1.178	1.187	0.905
Variance	1.952	0.892	0.828	2.705	1.603	1.009	1.400	1.413	0.808
Student’s t-test * (2.306)	0.561	1.013	–	0.311	0.899	–	1.641	1.186	–
F-value * (6.388)	2.358	1.077	–	2.680	1.588	–	1.733	1.749	–

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