BMC Chemistry

Table 6 Determination of FPV, LDP and MFX in pharmaceutical preparations and co-formulated dosage form using the described models

From: Green chemometric-assisted UV-spectrophotometric methods for the determination of favipiravir, cefixime and moxifloxacin hydrochloride as an effective therapeutic combination for COVID-19; application in pharmaceutical form and spiked human plasma

Favipiravir® 400 mg/tablet			Moxinow® 400 & 400 mg/tablet						Co-formulated dosage form
FPV			CEF			MFX			FPV			CEF			MFX
Conc (μg/mL)	PLS % R^*	GA-PLS % R^*	Conc (μg/mL)	PLS % R^*	GA-PLS % R^*	Conc (μg/mL)	PLS % R^*	GA-PLS % R^*	Conc (μg/mL)	PLS % R^*	GA-PLS % R^*	Conc (μg/mL)	PLS % R^*	GA-PLS % R^*	Conc (μg/mL)	PLS % R^*	GA-PLS % R^*
3	97.65	99.31	3	100.59	101.24	3	98.94	99.45	3	101.46	100.60	3	102.21	98.17	3	98.20	101.13
4	101.13	98.42	4	99.79	100.96	4	101.36	100.87	4	99.73	98.84	4	101.59	97.69	4	97.48	100.45
5	100.46	100.15	5	97.56	98.54	5	101.81	98.39	5	101.34	100.44	5	101.46	97.44	5	99.32	102.24
6	99.52	99.83	6	101.47	101.63	6	100.48	101.17	6	100.86	99.99	6	101.39	97.38	6	98.38	101.24
7	100.78	100.95	7	98.12	99.75	7	99.65	100.86	7	101.34	100.46	7	101.51	97.48	7	98.79	101.68
Mean	99.91	99.73	Mean	99.51	100.42	Mean	100.45	100.15	Mean	100.94	100.07	Mean	101.63	97.63	Mean	98.43	101.35
%RSD	1.398	0.947	%RSD	1.653	1.261	%RSD	1.178	1.187	%RSD	0.713	0.722	%RSD	0.327	0.333	%RSD	0.698	0.656

^*Average of three determinations

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ISSN: 2661-801X

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