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Table 5 Cell cycle analysis in HepG2 using compounds 7b, 15b, 16a and 16c

From: Synthesis, anticancer evaluation, molecular docking and ADME study of novel pyrido[4ʹ,3ʹ:3,4]pyrazolo[1,5-a]pyrimidines as potential tropomyosin receptor kinase A (TrKA) inhibitors

Compound no

Results

DNA content

Code

%G0-G1

%S

%G2/M

%Pre-G1

Comment

7b/HepG2

38.42

26.88

34.70

24.89

cell growth arrest@G2/M

15b/HepG2

33.57

29.71

36.72

32.51

cell growth arrest@G2/M

16a/HepG2

42.11

36.15

21.74

15.33

cell growth arrest@G2/M

16c/HepG2

41.61

31.94

26.45

12.07

cell growth arrest@G2/M

cont. HepG2

46.07

44.92

9.01

1.38

–

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BMC Chemistry

ISSN: 2661-801X

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