Fig. 4

Structures of the P. falciparum-derived proteins were predicted to be potential targets for compounds 2 (limonin), 3 (luteolin), and 5 (myricetin). Blue nodes (derived from the PPI network in Fig. 2) represent the proteasome system that limonin (2) was predicted to target one of its key proteins (i.e., the 20S proteasome). Red nodes represent the proteins involved in the glycerophospholipid metabolism that luteolin (3)  and myricetin (5) were predicted to target two of their key proteins (choline kinase and phosphocholine cytidylyltransferase, respectively)