Table 3 Calibrators and quality control samples of the six drugs in spiked human plasma
Drugs | Calibrator samples (µg/mL) | QC samples (µg/mL) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
C1 | C2 | C3 | C4 | C5 | C6 | C7 | LLOQ | QCL | QCM | QCH | |
IMP | 10.0 | 15.0 | 25.0 | 35.0 | 50.0 | 70.0 | 100.0 | 10.0 | 30.0 | 40.0 | 75.0 |
ETP | 15.0 | 50.0 | 100.0 | 150.0 | 200.0 | 300.0 | 400.0 | 15.0 | 50.0 | 140.0 | 280.0 |
CLS | 10.0 | 15.0 | 25.0 | 35.0 | 50.0 | 70.0 | 100.0 | 10.0 | 30.0 | 40.0 | 75.0 |
MRP | 5.0 | 10.0 | 20.0 | 30.0 | 50.0 | 70.0 | 100.0 | 5.0 | 15.0 | 35.0 | 75.0 |
PRB | 5.0 | 10.0 | 20.0 | 30.0 | 50.0 | 70.0 | 100.0 | 5.0 | 15.0 | 35.0 | 75.0 |
WRF | 1.0 | 3.0 | 7.0 | 10.0 | 15.0 | 20.0 | 30.0 | 1.0 | 6.0 | 12.0 | 25.0 |