From: Stress degradation studies and stability-indicating TLC-densitometric method of glycyrrhetic acid
Degradation conditions | Time (hour) | Rfof degraded products | Compound remained (ng /1000ng±S.D., n=3) | % Recovery |
---|---|---|---|---|
Acidic hydrolysis a | ||||
1N HCl | 2 | 0.08, 0.1,0.64 | 362.19±7.7 | 36.21 |
5N HCl | 2 | 0.08,0.1, 0.12, 0.64 | 253.83±1.5 | 25.38 |
Basic hydrolysis a | ||||
0.1N NaOH | 2 | Not detected | 999.9±5.2 | 99.9 |
1N NaOH | 2 | Not detected | 892.9±11 | 89.2 |
5N NaOH | 2 | Not detected | - | 100b |
Oxidation | ||||
35%v/v H2O2a | 2 | Not detected | 993.07±5.5 | 99.3 |
Oxidation at room temp | 24 | Not detected | 987.8±6.4 | 98.7 |
Neutral hydrolysis a | 2 | Not detected | 997.09±7.7 | 99.7 |
Wet heating a | 2 | Not detected | 999.47±9.5 | 99.9 |
Dry heating | 4 | Not detected | 999.58±6.2 | 99.9 |
Photostability- daylight | 24 | 0.35,0.38,0.49 | 663.74±5.1 | 66.3 |