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Table 1 Growth inhibition effect of various constituents of Cyrtomium fortumei (J.) Smith on different cell lines

From: Discovery and antitumor activities of constituents from Cyrtomium fortumei(J.) Smith rhizomes

Test extracts and compounds

Inhibitory Rate for Different Cell Lines (%, mean ± SD)a

 

MGC-803b

PC3c

A375d

NIH3T3e

Petroleum ether extract f

56.7 ± 3.7

68.0 ± 1.9

60.5 ± 3.2

7.1 ± 3.8

Ethyl acetate extract f

80.3 ± 2.8

89.6 ± 1.5

88.7 ± 3.3

45.6 ± 4.0

n-BuOH extract f

87.2 ± 3.9

80.2 ± 2.4

85.2 ± 3.7

53.5 ± 8.6

ADM

93.2 ± 1.6

95.1 ± 2.6

95.2 ± 2.4

98.5 ± 1.7

Protocate chaldehyde (1)

17.8 ± 3.1

30.5 ± 2.4

25.7 ± 3.1

12.1 ± 3.7

Woodwardinsaure methylester (2)

47.9 ± 9.3

33.2 ± 2.8

41.4 ± 5.6

15.2 ± 2.6

PPI (3)

67.1 ± 5.3

57.2 ± 4.2

45.8 ± 7.8

24.8 ± 3.4

Physcion (5)

28.9 ± 2.2

20.7 ± 1.2

15.7 ± 5.9

4.5 ± 2.6

Ursolic acid (6)

52.6 ± 2.4

55.8 ± 3.1

43.2 ± 1.3

23.4 ± 3.3

Sitost-4-en-3-one (7)

35.8 ± 2.6

15.3 ± 5.8

26.4 ± 5.1

5.2 ± 2.7

Betulin (8)

45.1 ± 3.1

18.4 ± 3.1

33.9 ± 5.6

29.8 ± 2.5

3′,4′,5-Trihydroxy-3,7-dimethoxyflavone (9)

25.6 ± 3.9

20.3 ± 2.5

11.2 ± 6.2

10.0 ± 2.9

Woodwardinic acid (10)

25.1 ± 5.3

25.2 ± 1.3

38.6 ± 4.0

6.9 ± 2.0

Sutchuenoside A (12)

19.9 ± 9.8

12.3 ± 4.4

34.8 ± 5.3

8.8 ± 4.2

Kaempferol-3, 7-O-α-L-dirhamnoside (14)

21.5 ± 7.0

17.8 ± 5.5

36.7 ± 3.9

23.1 ± 3.2

(-)-Epicatchin (15)

45.5 ± 4.1

50.6 ± 1.6

45.3 ± 3.2

22.5 ± 3.8

(+)-Catechin hydrate (16)

52.1 ± 5.7

49.6 ± 2.3

46.8 ± 1.1

28.9 ± 4.3

Kampferol (17)

54.5 ± 2.4

44.3 ± 2.5

47.3 ± 1.9

12.2 ± 3.4

Crassirhizomoside A (20)

11.4 ± 2.3

20.8 ± 6.0

34.9 ± 2.7

12.5 ± 5.2

Kaempferol-3-O-(3-O-acetyl-α-L-rhamnopyranoside) (21)

22.6 ± 8.0

15.6 ± 6.1

17.8 ± 3.3

9.9 ± 6.1

  1. Note: a Inhibitory percentage of cells treated with 20 μM of each compound for 72 h and SD = standard deviation; b Stomach cancer; c Prostate cancer; d Malignant melanoma; e Mouse fibroblasts; f Inhibitory percentage of cells treated with 200 μg/mL of each extract for 72 h.