Development of a method for environmentally friendly chemical peptide synthesis in water using water-dispersible amino acid nanoparticles

Table 1 In-water solid-phase coupling reaction using water-dispersible nanoparticles^a

Entry	Reagent	Additive	Base	Time [min]	Yield [%] ^b
1	WSCI	HONB	DIEA	15	68
2	WSCI	HONB	DIEA	30	100

^aReactions were carried out between water-dispersible Fmoc-Phe-OH nanoparticles and H-Leu-Rink amide TentaGel resin. ^bAfter reaction the resin was hydrized and Phe and Leu content in hydrolysates were analyzed. The yield of coupling reaction was calculated from the amino acid ration of Phe and Leu by amino acid analysis.

ISSN: 2661-801X