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  1. Research article

    Phenolic compounds, flavonoids, lipids and antioxidant potential of apricot (Prunus armeniaca L.) pomace fermented by two filamentous fungal strains in solid state system

    The use of agricultural and food by-products is an economical solution to industrial biotechnology. The apricot press residues are abounding by-products from juice industry which can be used as substrates in s...

    Francisc Vasile Dulf, Dan Cristian Vodnar, Eva-Henrietta Dulf and Adela Pintea

    Chemistry Central Journal 2017 11:92

    Published on: 21 September 2017

  2. Research article

    Reversible uptake of molecular oxygen by heteroligand Co(II)–l-α-amino acid–imidazole systems: equilibrium models at full mass balance

    The paper examines Co(II)–amino acid–imidazole systems (where amino acid = l-α-amino acid: alanine, asparagine, histidine) which, when in aqueous solutions, activate and reversibly take up dioxygen, while maintai...

    Marek Pająk, Magdalena Woźniczka, Andrzej Vogt and Aleksander Kufelnicki

    Chemistry Central Journal 2017 11:90

    Published on: 19 September 2017

  3. Research Article

    Synthesis, molecular docking and biological evaluation of bis-pyrimidine Schiff base derivatives

    Heterocyclic pyrimidine nucleus, which is an essential base component of the genetic material of deoxyribonucleic acid, demonstrated various biological activities. A series of bis-pyrimidine Schiff bases were ...

    Sanjiv Kumar, Siong Meng Lim, Kalavathy Ramasamy, Mani Vasudevan, Syed Adnan Ali Shah, Manikandan Selvaraj and Balasubramanian Narasimhan

    Chemistry Central Journal 2017 11:89

    Published on: 18 September 2017

  4. Research article

    Novel pyridine-based Pd(II)-complex for efficient Suzuki coupling of aryl halides under microwaves irradiation in water

    Suzuki C–C cross-coupling of aryl halides with aryl boronic acids using new phosphene-free palladium complexes as precatalysts was investigated. A pyridine-based Pd(II)-complex was used in open air under therm...

    Ismail I. Althagafi, Mohamed R. Shaaban, Aisha Y. Al-dawood and Ahmad M. Farag

    Chemistry Central Journal 2017 11:88

    Published on: 18 September 2017

  5. Research Article

    Formation of amides: one-pot condensation of carboxylic acids and amines mediated by TiCl4

    A general procedure for the synthesis of amides via the direct condensation of carboxylic acids and amines in the presence of TiCl4 is reported. The amidation reaction was performed in pyridine at 85 °C with a wi...

    Antonella Leggio, Jessica Bagalà, Emilia Lucia Belsito, Alessandra Comandè, Marianna Greco and Angelo Liguori

    Chemistry Central Journal 2017 11:87

    Published on: 15 September 2017

  6. Research article

    The development of an effective synthetic route of lesinurad (RDEA594)

    Lesinurad is a novel selective uric acid salt transport protein 1 (URAT1) inhibitor which is approved in the USA for the treatment of gout. However, there are some shortcomings among the reported synthetic rou...

    Qing Meng, Tong Zhao, Dongwei Kang, Boshi Huang, Peng Zhan and Xinyong Liu

    Chemistry Central Journal 2017 11:86

    Published on: 5 September 2017

  7. Research article

    Synthesis, characterization, anti-ulcer action and molecular docking evaluation of novel benzimidazole-pyrazole hybrids

    A series of six novel benzimidazole-pyrazole hybrid molecules was synthesized and characterized using elemental analysis (CHN) and spectroscopic methods (1HNMR, FT-IR). All the synthesized compounds were evaluate...

    Abida Noor, Neelum Gul Qazi, Humaira Nadeem, Arif-ullah Khan, Rehan Zafar Paracha, Fawad Ali and Adil Saeed

    Chemistry Central Journal 2017 11:85

    Published on: 2 September 2017

  8. Research article

    Two phenolic antioxidants in Suoyang enhance viability of •OH-damaged mesenchymal stem cells: comparison and mechanistic chemistry

    Suoyang originates from a psammophyte named Cynomorium songaricum Rupr and has been known as a phenolic-antioxidant-enriched traditional Chinese herbal medicine. The present study atte...

    Yulu Xie, Xican Li, Jieying Xu, Qian Jiang, Hong Xie, Jianfeng He and Dongfeng Chen

    Chemistry Central Journal 2017 11:84

    Published on: 25 August 2017

  9. Research article

    Comprehensive spectral identification of key intermediates to the final product of the chiral pool synthesis of radezolid

    Radezolid (RAD, 12), biaryl oxazolidinone, was synthesised with small modifications according to the methods described in the literature. The pharmacological activity is observed only for (S)-enantiomer, therefor...

    Katarzyna Michalska, Elżbieta Bednarek, Ewa Gruba, Kornelia Lewandowska, Mikołaj Mizera and Judyta Cielecka-Piontek

    Chemistry Central Journal 2017 11:82

    Published on: 9 August 2017

  10. Research article

    One-step multicomponent synthesis of chiral oxazolinyl-zinc complexes

    Typically, oxazolinyl metal complexes are synthesized in two steps, where the free ligand is prepared by the condensation reaction between a functionalized nitrile and an amino alcohol in the presence of a Lew...

    Mei Luo, Jing Cheng Zhang, Wen Min Pang and King Kuok Hii

    Chemistry Central Journal 2017 11:81

    Published on: 9 August 2017

    The Erratum to this article has been published in Chemistry Central Journal 2017 11:91

  11. Research article

    Bis-pyrimidine acetamides: design, synthesis and biological evaluation

    In the past few years, increased resistance of microorganisms towards antimicrobial agents become a serious health problem, so there is a need for the discovery of new antimicrobial agents. On the other hand, ...

    Sanjiv Kumar, Siong Meng Lim, Kalavathy Ramasamy, Mani Vasudevan, Syed Adnan Ali Shah and Balasubramanian Narasimhan

    Chemistry Central Journal 2017 11:80

    Published on: 8 August 2017

  12. Research article

    Comparison of various techniques for the extraction of umbelliferone and herniarin in Matricaria chamomilla processing fractions

    Chamomile, a well-known medicinal plant, is a rich source of bioactive compounds, among which two coumarin derivatives, umbelliferone and herniarin, are often found in its extracts. Chamomile extracts have fou...

    Maja Molnar, Nikolina Mendešević, Drago Šubarić, Ines Banjari and Stela Jokić

    Chemistry Central Journal 2017 11:78

    Published on: 5 August 2017

  13. Research article

    Antimicrobial activity of thiophene derivatives derived from ethyl (E)-5-(3-(dimethylamino)acryloyl)-4-methyl-2-(phenylamino)thiophene-3-carboxylate

    The thiophene nucleus has been recognized as an important entity in the synthesis of heterocyclic compounds with promising pharmacological characteristics.

    Yahia Nasser Mabkhot, Nahed Ahmed Kaal, Seham Alterary, Salem S. Al-Showiman, Thoraya A. Farghaly and Mohammad S. Mubarak

    Chemistry Central Journal 2017 11:75

    Published on: 3 August 2017

  14. Research article

    Regioselective semi-synthesis of 6-isomers of 5,8-O-dimethyl ether of shikonin derivatives via an ‘intramolecular ring-closing/ring-opening’ strategy as potent anticancer agents

    Synthesis of 6-isomer of 5,8-O-dimethyl ether of shikonin (13), a promising anticancer scaffold, always remains a huge challenge. Herein a key intermediate for 13, 2-(1-hydroxyl-4-methyl-3-pentenyl)-1,4,5,8-tetra...

    Li Zhou, Xu Zhang and Wen Zhou

    Chemistry Central Journal 2017 11:74

    Published on: 2 August 2017

  15. Research article

    Ultra-high resolution X-ray structures of two forms of human recombinant insulin at 100 K

    The crystal structure of a commercially available form of human recombinant (HR) insulin, Insugen (I), used in the treatment of diabetes has been determined to 0.92 Å resolution using low temperature, 100 K, s...

    David R. Lisgarten, Rex A. Palmer, Carina M. C. Lobley, Claire E. Naylor, Babur Z. Chowdhry, Zakieh I. Al-Kurdi, Adnan A. Badwan, Brendan J. Howlin, Nicholas C. J. Gibbons, José W. Saldanha, John N. Lisgarten and Ajit K. Basak

    Chemistry Central Journal 2017 11:73

    Published on: 1 August 2017

  16. Research article

    Structural optimization and evaluation of novel 2-pyrrolidone-fused (2-oxoindolin-3-ylidene)methylpyrrole derivatives as potential VEGFR-2/PDGFRβ inhibitors

    Tumor angiogenesis, essential for tumor growth and metastasis, is tightly regulated by VEGF/VEGFR and PDGF/PDGFR pathways, and therefore blocking those pathways is a promising therapeutic target. Compared to s...

    Ting-Hsuan Yang, Chun-I Lee, Wen-Hsin Huang and An-Rong Lee

    Chemistry Central Journal 2017 11:72

    Published on: 1 August 2017

  17. Research article

    Structural effects on kinetics and a mechanistic investigation of the reaction between DMAD and N–H heterocyclic compound in the presence of triphenylarsine: spectrophotometry approach

    Kinetics and a mechanistic investigation of the reaction between dimethyl acetylenedicarboxcylate (DMAD) and saccharin (NH heterocyclic compound) has been spectrally studied in methanol environment in the presen...

    Sayyed Mostafa Habibi-Khorassani, Mehdi Shahraki and Mahdieh Darijani

    Chemistry Central Journal 2017 11:71

    Published on: 1 August 2017

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