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  1. Research article

    Evaluation of water quality and human risk assessment due to heavy metals in groundwater around Muledane area of Vhembe District, Limpopo Province, South Africa

    Groundwater is considered as good alternative to potable water because of its low turbidity and perceived low contamination. The study assessed the physio-chemical and heavy metals concentrations in eight rand...

    Joshua Nosa Edokpayi, Abimbola Motunrayo Enitan, Ntwanano Mutileni and John Ogony Odiyo

    Chemistry Central Journal 2018 12:2

    Published on: 12 January 2018

  2. Research Article

    Synthesis, anti-microbial activity, cytotoxicity of some novel substituted (5-(3-(1H-benzo[d]imidazol-2-yl)-4-hydroxybenzyl)benzofuran-2-yl)(phenyl)methanone analogs

    There is a dire need for the discovery and development of new antimicrobial agents after several experiments for a better resistance of microorganisms towards antimicrobial agents become a serious health probl...

    Bhookya Shankar, Pochampally Jalapathi, Balabadra Saikrishna, Shaym Perugu and Vijjulatha Manga

    Chemistry Central Journal 2018 12:1

    Published on: 9 January 2018

  3. Research Article

    Regioselective alkali metal reduction of dibenzocyclooctadiene lignan derivatives, demethoxylation followed by dehalogenation

    The regioselective demethoxylation and dehalogenation of dihalogenated dibenzocyclooctadiene lignans derivatives were realized in a one-step reaction with excellent yields in the sodium and t-butanol reaction sys...

    Qing-yao Wang, Jia-qi Fang, Lu-lu Deng, Xiao-jiang Hao and Shu-zhen Mu

    Chemistry Central Journal 2017 11:138

    Published on: 27 December 2017

  4. Research Article

    Synthesis, characterization, biological evaluation and molecular docking studies of 2-(1H-benzo[d]imidazol-2-ylthio)-N-(substituted 4-oxothiazolidin-3-yl) acetamides

    A series of 2-(1H-benzo[d]imidazol-2-ylthio)-N-(substituted 4-oxothiazolidin-3-yl) acetamides was synthesized and characterized by physicochemical and spectral means. The synthesized compounds were evaluated for ...

    Snehlata Yadav, Balasubramanian Narasimhan, Siong M. Lim, Kalavathy Ramasamy, Mani Vasudevan, Syed Adnan Ali Shah and Manikandan Selvaraj

    Chemistry Central Journal 2017 11:137

    Published on: 22 December 2017

  5. Research article

    LC–MS/MS method for the quantification of masitinib in RLMs matrix and rat urine: application to metabolic stability and excretion rate

    Masitinib (MST) is a selective tyrosine kinase inhibitor. Validated liquid chromatography tandem mass spectrometric method (LC–MS/MS) was developed for the quantification of MST in rat liver microsomes (RLMs) ...

    Sawsan M. Amer, Adnan A. Kadi, Hany W. Darwish and Mohamed W. Attwa

    Chemistry Central Journal 2017 11:136

    Published on: 22 December 2017

  6. Research Article

    N-Benzoyl dithieno[3,2-b:2′,3′-d]pyrrole-based hyperbranched polymers by direct arylation polymerization

    Although poly(N-acyl dithieno[3,2-b:2′,3′-d]pyrrole)s have attracted great attention as a new class of conducting polymers with highly stabilized energy levels, hyperbranched polymers based on this monomer type ...

    Tam Huu Nguyen, Thu Anh Nguyen, Hoan Minh Tran, Le-Thu T. Nguyen, Anh Tuan Luu, Jun Young Lee and Ha Tran Nguyen

    Chemistry Central Journal 2017 11:135

    Published on: 21 December 2017

  7. Research Article

    Study of binding interaction of rivaroxaban with bovine serum albumin using multi-spectroscopic and molecular docking approach

    Rivaroxaban is a direct inhibitor of coagulation factor Xa and is used for venous thromboembolic disorders. The rivaroxaban interaction with BSA was studied to understand its PK and PD (pharmacokinetics and ph...

    Tanveer A. Wani, Haitham AlRabiah, Ahmed H. Bakheit, Mohd Abul Kalam and Seema Zargar

    Chemistry Central Journal 2017 11:134

    Published on: 20 December 2017

  8. Research Article

    Design, synthesis and biological evaluation of antimalarial activity of new derivatives of 2,4,6-s-triazine

    Dihydrofolate reductase (DHFR) is an important enzyme for de novo synthesis of nucleotides in Plasmodium falciparum and it is essential for cell proliferation. DHFR is a well known antimalarial target for drugs l...

    Mallika Pathak, Himanshu Ojha, Anjani K. Tiwari, Deepti Sharma, Manisha Saini and Rita Kakkar

    Chemistry Central Journal 2017 11:132

    Published on: 19 December 2017

  9. Research Article

    Comprehensive survey of radionuclides in contemporary smokeless tobacco products

    There is considerable interest in the chemical composition of smokeless tobacco products (STPs), owing to health concerns associated with their use. Previous studies have documented levels of 210Po, 210Pb and ura...

    K. McAdam, H. Kimpton, A. Porter, C. Liu, A. Faizi, M. Mola, J. McAughey and B. Rodu

    Chemistry Central Journal 2017 11:131

    Published on: 19 December 2017

  10. Review

    Biological potential of thiazolidinedione derivatives of synthetic origin

    Thiazolidinediones are sulfur containing pentacyclic compounds that are widely found throughout nature in various forms. Thiazolidinedione nucleus is present in numerous biological compounds, e.g., anti-malari...

    Sucheta, Sumit Tahlan and Prabhakar Kumar Verma

    Chemistry Central Journal 2017 11:130

    Published on: 8 December 2017

  11. Research article

    Synthesis, structure and toxicity evaluation of ethanolamine nitro/chloronitrobenzoates: a combined experimental and theoretical study

    Nitroaromatic and chloronitroaromatic compounds have been a subject of great interest in industry and recently in medical-pharmaceutic field. 2-Chloro-4-nitro/2-chloro-5-nitrobenzoic acids and 4-nitrobenzoic a...

    Manuela Crisan, Liliana Halip, Paulina Bourosh, Sergiu Adrian Chicu and Yurii Chumakov

    Chemistry Central Journal 2017 11:129

    Published on: 6 December 2017

  12. Research Article

    Synthesis and analytical characterization of new thiazol-2-(3H)-ones as human neutrophil elastase (HNE) inhibitors

    Human neutrophil elastase (HNE) is a potent serine protease belonging to the chymotrypsin family and is involved in a variety of pathologies affecting the respiratory system. Thus, compounds able to inhibit HN...

    Letizia Crocetti, Gianluca Bartolucci, Agostino Cilibrizzi, Maria Paola Giovannoni, Gabriella Guerrini, Antonella Iacovone, Marta Menicatti, Igor A. Schepetkin, Andrei I. Khlebnikov, Mark T. Quinn and Claudia Vergelli

    Chemistry Central Journal 2017 11:127

    Published on: 6 December 2017

  13. Research article

    Investigating and characterizing the binding activity of the immobilized calmodulin to calmodulin-dependent protein kinase I binding domain with atomic force microscopy

    Protein–protein interactions are responsible for many biological processes, and the study of how proteins undergo a conformational change induced by other proteins in the immobilized state can help us to under...

    Xiaoning Zhang and Hongmei Hu

    Chemistry Central Journal 2017 11:128

    Published on: 6 December 2017

  14. Research Article

    Development of new analytical methods for the determination of caffeine content in aqueous solution of green coffee beans

    This study was conducted to develop fast and cost effective methods for the determination of caffeine in green coffee beans. In the present work direct determination of caffeine in aqueous solution of green co...

    Blen Weldegebreal, Mesfin Redi-Abshiro and Bhagwan Singh Chandravanshi

    Chemistry Central Journal 2017 11:126

    Published on: 5 December 2017

  15. Research Article

    Structure-dependent optoelectronic properties of perylene, di-indenoperylene (DIP) isolated molecule and DIP molecular crystal

    Theoretical simulations were designed by first principles approach of density functional theory to investigate the structural and optoelectronic properties of different structural classes of perylene; isolated...

    Mazmira Mohamad, Rashid Ahmed, Amirudin Shaari and Souraya Goumri-Said

    Chemistry Central Journal 2017 11:125

    Published on: 2 December 2017

  16. Research Article

    An improved solvent-free synthesis of flunixin and 2-(arylamino) nicotinic acid derivatives using boric acid as catalyst

    A simple solvent-free protocol for the preparation of flunixin, a potent non-narcotic, non-steroidal anti-inflammatory drugs is reported using boric acid as catalyst. Its salt, flunixin meglumine are then prep...

    Mahsa Yarhosseini, Shahrzad Javanshir, Zahra Dolatkhah and Mohammad G. Dekamin

    Chemistry Central Journal 2017 11:124

    Published on: 1 December 2017

  17. Research Article

    Synthesis, anti-angiogenic and DNA cleavage studies of novel N-(4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)piperidine-4-carboxamide derivatives

    A series of novel N-(4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)piperidine-4-carboxamide derivatives 10(af), 12(ac) and 14(ac) were synthesized and characterized by FTIR, 1H-NMR, mass spectral an...

    Vinaya Kambappa, G. K. Chandrashekara, N. D. Rekha, Prasanna D. Shivaramu and Komaraiah Palle

    Chemistry Central Journal 2017 11:122

    Published on: 30 November 2017

  18. Correction

    Correction to: Synthesis, characterization and in vitro antimicrobial activity of novel fused pyrazolo[3,4-c]pyridazine, pyrazolo[3,4-d]pyrimidine, thieno[3,2-c] pyrazole and pyrazolo[3′,4′:4,5]thieno[2,3-d]pyrimidine derivatives

    After the publication of this work [1] it was noticed that on page 3 of the article beginning in the paragraph—‘Hydrazide 14 is used as a key producer…’ the compound—“Not ethyl-N′-5-amino-1,3-diphenyl-1H-thieno[3...

    Mohamed A. M. Abdel Reheim and Safaa M. Baker

    Chemistry Central Journal 2017 11:123

    Published on: 30 November 2017

    The original article was published in Chemistry Central Journal 2017 11:112

  19. Research Article

    Determination of lesinurad in rat plasma by a UHPLC–MS/MS assay

    Lesinurad is an oral inhibitor of urate-anion exchanger transporter 1 and has been approved by the US Food and Drug Administration for combination therapy with a xanthine oxidase inhibitor for the treatment of...

    Xiao-Yang Zhou, Ling-Jing Yuan, Zhe Chen, Peng-Fei Tang, Xiang-Yu Li, Guo-Xin Hu and Jian-Ping Cai

    Chemistry Central Journal 2017 11:121

    Published on: 28 November 2017

  20. Research article

    Electrochemical behavior and in-vitro antimicrobial screening of some thienylazoaryls dyes

    A series of recently reported phenolic azo dyes 7a–e were prepared by coupling the thienyl diazonium sulfate of 3-Amino-4H-benzo[f]thieno[3,4-c](2H)chromen-4-one with selected diversely substituted phenolic and n...

    Joseph Tsemeugne, Emmanuel Sopbué Fondjo, Jean-de-Dieu Tamokou, Ignas Tonle, Irene Chinda Kengne, Arnaud Djintchui Ngongang, Stephen Tamekou Lacmata, Taoufik Rohand, Jules Roger Kuiate and Beibam Luc Sondengam

    Chemistry Central Journal 2017 11:119

    Published on: 21 November 2017

  21. Research article

    Polysaccharides from Dolichos biflorus Linn and Trachyspermum ammi Linn seeds: isolation, characterization and remarkable antimicrobial activity

    Polysaccharides are structurally complex and essential constituents of life, and therefore, studies directed to these kinds of molecules have received scientific attention. Despite an easy availability of Dolicho...

    Shibani Basu, Manojit Ghosh, Rupam Kumar Bhunia, Jhuma Ganguly and Bimal K. Banik

    Chemistry Central Journal 2017 11:118

    Published on: 21 November 2017

  22. Research article

    Study on the interaction of paeoniflorin with human serum albumin (HSA) by spectroscopic and molecular docking techniques

    The interaction of paeoniflorin with human serum albumin (HSA) was investigated using fluorescence, UV–vis absorption, circular dichroism (CD) spectra and molecular docking techniques under simulative physiolo...

    Liang Xu, Yan-Xi Hu, Yan-Cheng Li, Yu-Feng Liu, Li Zhang, Hai-Xin Ai and Hong-Sheng Liu

    Chemistry Central Journal 2017 11:116

    Published on: 17 November 2017

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