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  1. Research article

    Novel drug targets for Mycobacterium tuberculosis: 2-heterostyrylbenzimidazoles as inhibitors of cell wall protein synthesis

    Multi drug-resistant and mycobacterial infections are a major public health challenge, leading to high mortality and socioeconomic burdens through worldwide. Novel therapeutics are necessary to treat the drug ...

    Mohana Rao Anguru, Ashok Kumar Taduri, Rama Devi Bhoomireddy, Malathi Jojula and Shravan Kumar Gunda

    Chemistry Central Journal 2017 11:68

    Published on: 24 July 2017

  2. Research article

    One pot synthesis, antimicrobial and antioxidant activities of fused uracils: pyrimidodiazepines, lumazines, triazolouracil and xanthines

    Uracil derivatives have a great attraction because they play an important role in pharmacological activities. Pyrimidodiazepines, lumazines, triazolopyrimidines and xanthines have significant wide spectrum act...

    Samar A. El-Kalyoubi, Eman A. Fayed and Ahmed S. Abdel-Razek

    Chemistry Central Journal 2017 11:66

    Published on: 19 July 2017

    The Erratum to this article has been published in Chemistry Central Journal 2017 11:69

  3. Methodology

    RD-Metabolizer: an integrated and reaction types extensive approach to predict metabolic sites and metabolites of drug-like molecules

    Experimental approaches for determining the metabolic properties of the drug candidates are usually expensive, time-consuming and labor intensive. There is a great deal of interest in developing computational ...

    Jiajia Meng, Shiliang Li, Xiaofeng Liu, Mingyue Zheng and Honglin Li

    Chemistry Central Journal 2017 11:65

    Published on: 18 July 2017

  4. Research article

    Comparative study of phenolic compounds, vitamin E, and fatty acids compositional profiles in black seed-coated soybeans (Glycine Max (L.) Merrill) depending on pickling period in brewed vinegar

    Pickled soybeans or vinegar beans have long been used as a folk remedy and also a supplemental nutritional source in Korea. In general the pickling process in vinegar improves the digestibility of soybeans as ...

    Ill-Min Chung, Jin-Young Oh and Seung-Hyun Kim

    Chemistry Central Journal 2017 11:64

    Published on: 18 July 2017

  5. Research article

    Using crystallography, topology and graph set analysis for the description of the hydrogen bond network of triamterene: a rational approach to solid form selection

    This study has demonstrated the use of crystallography, topology and graph set analysis in the description and classification of the complex hydrogen bonded network of triamterene. The aim is to give a brief o...

    David S. Hughes, Amit Delori, Abida Rehman and William Jones

    Chemistry Central Journal 2017 11:63

    Published on: 13 July 2017

  6. Review

    Selective synthesis of Fe3O4Au x Ag y nanomaterials and their potential applications in catalysis and nanomedicine

    In these recent years, magnetite (Fe3O4) has witnessed a growing interest in the scientific community as a potential material in various fields of application namely in catalysis, biosensing, hyperthermia treatme...

    Essy Kouadio Fodjo, Koffi Mouroufié Gabriel, Brou Yapi Serge, Dan Li, Cong Kong and Albert Trokourey

    Chemistry Central Journal 2017 11:58

    Published on: 24 June 2017

  7. Research article

    Antiproliferative and apoptotic effects of black turtle bean extracts on human breast cancer cell line through extrinsic and intrinsic pathway

    The black turtle bean (BTB) is most widely consumed legume all over the world having anticancer activity. The aim of the study was to analyse the apoptotic effects of BTB extracts on human breast cancer cell l...

    Suresh Kumar, Vinay Kumar Sharma, Savita Yadav and Sharmistha Dey

    Chemistry Central Journal 2017 11:56

    Published on: 20 June 2017

  8. Research article

    Effects of temperature, time, and solvent ratio on the extraction of phenolic compounds and the anti-radical activity of Clinacanthus nutans Lindau leaves by response surface methodology

    Clinacanthus nutans Lindau is a well-known plant, native to tropical Asian countries. Reports on this plant that is rich in phenolic compounds have focused on its therapeutic anti-infl...

    Intan Soraya Che Sulaiman, Mahiran Basri, Hamid Reza Fard Masoumi, Wei Jian Chee, Siti Efliza Ashari and Maznah Ismail

    Chemistry Central Journal 2017 11:54

    Published on: 14 June 2017

  9. Research article

    Synthesis of some new pyrazolo[1,5-a]pyrimidine, pyrazolo[5,1-c]triazine, 1,3,4-thiadiazole and pyridine derivatives containing 1,2,3-triazole moiety

    Pyrazolo[1,5-a]pyrimidines are purine analogues. They have beneficial properties as antimetabolites in purine biochemical reactions. This division compounds have attracted wide pharmaceutical interest because of ...

    Nadia A. Abdelriheem, Yasser H. Zaki and Abdou O. Abdelhamid

    Chemistry Central Journal 2017 11:53

    Published on: 12 June 2017

  10. Research article

    Synthesis, characterization, X-ray structure, computational studies, and bioassay of novel compounds combining thiophene and benzimidazole or 1,2,4-triazole moieties

    Due to their interesting and versatile biological activity, thiophene-containing compounds have attracted the attention of both chemists and medicinal chemists. Some of these compounds have anticancer, antibac...

    Yahia N. Mabkhot, Salim S. Al-Showiman, Saied M. Soliman, Hazem A. Ghabbour, Murad A. AlDamen and Mohammad S. Mubarak

    Chemistry Central Journal 2017 11:51

    Published on: 9 June 2017

  11. Research article

    Synthesis and insecticidal activity of diacylhydrazine derivatives containing a 3-bromo-1-(3-chloropyridin-2-yl)-1H-pyrazole scaffold

    The diacylhydrazine derivatives have attracted considerable attention in recently years due to their simple structure, low toxicity, and high insecticidal selectivity. As well as 3-bromo-1-(3-chloropyridin-2-y...

    Yanyan Wang, Fangzhou Xu, Gang Yu, Jun Shi, Chuanhui Li, A’li Dai, Zhiqian Liu, Jiahong Xu, Fenghua Wang and Jian Wu

    Chemistry Central Journal 2017 11:50

    Published on: 5 June 2017

  12. Research article

    Morphologically controlled synthesis of ferric oxide nano/micro particles and their catalytic application in dry and wet media: a new approach

    Morphologically controlled synthesis of ferric oxide nano/micro particles has been carried out by using solvothermal route. Structural characterization displays that the predominant morphologies are porous hol...

    Muhammad Ramzan Saeed Ashraf Janjua, Saba Jamil, Nazish Jahan, Shanza Rauf Khan and Saima Mirza

    Chemistry Central Journal 2017 11:49

    Published on: 31 May 2017

  13. Research article

    Molecular docking and biological evaluation of some thioxoquinazolin-4(3H)-one derivatives as anticancer, antioxidant and anticonvulsant agents

    The quinazoline are an important class of medicinal compounds that possess a number of biological activities like anticancer, anticonvulsant and antioxidant etc.

    Danah S. Al-Shamary, Monirah A. Al-Alshaikh, Nabila Abdelshafy Kheder, Yahia Nasser Mabkhot and Syed Lal Badshah

    Chemistry Central Journal 2017 11:48

    Published on: 31 May 2017

  14. Review

    Gadolinium-based layered double hydroxide and graphene oxide nano-carriers for magnetic resonance imaging and drug delivery

    Gadolinium (Gd)-based contrasts remain one of the most accepted contrast agents for magnetic resonance imaging, which is among the world most recognized noninvasive techniques employed in clinical diagnosis of...

    Muhammad Sani Usman, Mohd Zobir Hussein, Sharida Fakurazi and Fathinul Fikri Ahmad Saad

    Chemistry Central Journal 2017 11:47

    Published on: 30 May 2017

  15. Research article

    Liquid chromatography tandem mass spectrometry method for the quantification of vandetanib in human plasma and rat liver microsomes matrices: metabolic stability investigation

    Vandetanib (VNT) is a new oral tyrosine kinase inhibitor that acts mainly by inhibiting vascular endothelial growth factor receptor (VEGFR). Fast, specific, sensitive and validated LC–MS/MS was established for...

    Sawsan M. Amer, Adnan A. Kadi, Hany W. Darwish and Mohamed W. Attwa

    Chemistry Central Journal 2017 11:45

    Published on: 30 May 2017

  16. Research article

    Optimization of enzymatic esterification of dihydrocaffeic acid with hexanol in ionic liquid using response surface methodology

    Developing an efficient lipophilization reaction system for phenolic derivatives could enhance their applications in food processing. Low solubility of phenolic acids reduces the efficiency of phenolic derivat...

    Somayeh Gholivand, Ola Lasekan, Chin Ping Tan, Faridah Abas and Leong Sze Wei

    Chemistry Central Journal 2017 11:44

    Published on: 26 May 2017

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