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  1. Research article

    Design, synthesis, conformational and molecular docking study of some novel acyl hydrazone based molecular hybrids as antimalarial and antimicrobial agents

    Acyl hydrazones are an important class of heterocyclic compounds promising pharmacological characteristics. Malaria is a life-threatening mosquito-borne blood disease caused by a plasmodium parasite. In some p...

    Parvin Kumar, Kulbir Kadyan, Meenakshi Duhan, Jayant Sindhu, Vineeta Singh and Baljeet Singh Saharan

    Chemistry Central Journal 2017 11:115

    Published on: 14 November 2017

  2. Research article

    Simultaneous determination of brazilin and protosappanin B in Caesalpinia sappan by ionic-liquid dispersive liquid-phase microextraction method combined with HPLC

    The conditions of heating, ionic liquid-based ultrasonic-assisted extraction combined with reverse-phase high performance liquid chromatography were optimized to simultaneously isolate and determinate brazilin...

    Zhaoyang Xia, Dongdong Li, Qing Li, Yan Zhang and Wenyi Kang

    Chemistry Central Journal 2017 11:114

    Published on: 13 November 2017

  3. Research article

    Antimicrobial and antioxidant potential of different solvent extracts of the medicinal plant Geum urbanum L.

    Many Geum species are known to be rich in biologically active compounds and therefore could be a source of new natural products with pharmacological potential. The medicinal plant Geum urbanum L. is widespread in...

    Lyudmila Dimitrova, Maya M. Zaharieva, Milena Popova, Nedelina Kostadinova, Iva Tsvetkova, Vassya Bankova and Hristo Najdenski

    Chemistry Central Journal 2017 11:113

    Published on: 7 November 2017

  4. Research article

    Synthesis, characterization and in vitro antimicrobial activity of novel fused pyrazolo[3,4-c]pyridazine, pyrazolo[3,4-d]pyrimidine, thieno[3,2-c]pyrazole and pyrazolo[3′,4′:4,5]thieno[2,3-d]pyrimidine derivatives

    Some novel substituted pyrazolone, pyrazolo[3,4-c]pyridazine, pyrazolo[3,4-d]pyrimidine, pyrazolo[3,4-d]thiazolo[3,2-a]pyrimidinone, thieno[3,2-c]pyrazole and pyrazolo[3′,4′:4,5]thieno[2,3-d]pyrimidine derivative...

    Mohamed A. M. Abdel Reheim and Safaa M. Baker

    Chemistry Central Journal 2017 11:112

    Published on: 2 November 2017

    The Correction to this article has been published in Chemistry Central Journal 2017 11:123

  5. Research article

    Aromatherapy: composition of the gaseous phase at equilibrium with liquid bergamot essential oil

    This work compares the composition at different temperatures of gaseous phase of bergamot essential oil at equilibrium with the liquid phase. A new GC–MS methodology to determine quantitatively the volatile ar...

    Antonella Leggio, Vanessa Leotta, Emilia Lucia Belsito, Maria Luisa Di Gioia, Emanuela Romio, Ilaria Santoro, Domenico Taverna, Giovanni Sindona and Angelo Liguori

    Chemistry Central Journal 2017 11:111

    Published on: 2 November 2017

  6. Research article

    Antioxidant and antiproliferative activity of blue corn and tortilla from native maize

    Blue corn is a cereal rich in phenolic compounds used to make blue tortillas. Tortillas are an important part of the Mexican diet. Blue corn and tortilla represent an important source of the natural antioxidan...

    Mónica Y. Herrera-Sotero, Carlos D. Cruz-Hernández, Carolina Trujillo-Carretero, Mauricio Rodríguez-Dorantes, Hugo S. García-Galindo, José L. Chávez-Servia, Rosa M. Oliart-Ros and Rosa I. Guzmán-Gerónimo

    Chemistry Central Journal 2017 11:110

    Published on: 30 October 2017

  7. Research article

    Synthesis and biological activity of myricetin derivatives containing 1,3,4-thiadiazole scaffold

    Myricetin and 1,3,4-thiadiazole derivatives were reported to exhibit favorable antiviral and antibacterial activities. Aiming to discover novel myricetin analogues with potent activities, a series of novel myr...

    Xinmin Zhong, Xiaobin Wang, Lijuan Chen, Xianghui Ruan, Qin Li, Juping Zhang, Zhuo Chen and Wei Xue

    Chemistry Central Journal 2017 11:106

    Published on: 17 October 2017

  8. Research article

    Preparative HPLC for large scale isolation, and salting-out assisted liquid–liquid extraction based method for HPLC–DAD determination of khat (Catha edulis Forsk) alkaloids

    Khat (Catha edulis Forsk) is an evergreen shrub of the Celastraceae family. It is widely cultivated in Yemen and East Africa, where its fresh leaves are habitually chewed for their momentary pleasures and stimula...

    Minaleshewa Atlabachew, Bhagwan Singh Chandravanshi and Mesfin Redi-Abshiro

    Chemistry Central Journal 2017 11:107

    Published on: 17 October 2017

  9. Research article

    Synthesis, crystallographic characterization, molecular docking and biological activity of isoquinoline derivatives

    The main objective of this work was to synthesize novel compounds with a benzo[de][1,2,4]triazolo[5,1-a]isoquinoline scaffold by employing (dioxo-benzo[de]isoquinolin-2-yl) thiourea as a building block. Molecular...

    Hatem A. Abuelizz, Rashad Al-Salahi, Jamil Al-Asri, Jérémie Mortier, Mohamed Marzouk, Essam Ezzeldin, Azza A. Ali, Mona G. Khalil, Gerhard Wolber, Hazem A. Ghabbour, Abdulrahman A. Almehizia and Gehad A. Abdel Jaleel

    Chemistry Central Journal 2017 11:103

    Published on: 16 October 2017

  10. Research article

    A facile access and evaluation of some novel thiazole and 1,3,4-thiadiazole derivatives incorporating thiazole moiety as potent anticancer agents

    Many heterocyclic compounds containing thiazole or 1,3,4-thiadiazole ring in their skeletons have been reported to possess various pharmacological activities especially anticancer activities.

    Sobhi M. Gomha, Mohamad R. Abdelaziz, Nabila A. Kheder, Hassan M. Abdel-aziz, Seham Alterary and Yahia N. Mabkhot

    Chemistry Central Journal 2017 11:105

    Published on: 16 October 2017

  11. Research article

    Steam distillation/drop-by-drop extraction with gas chromatography–mass spectrometry for fast determination of volatile components in jujube (Ziziphus jujuba Mill.) extract

    Jujube extract is commonly used as a food additive and flavoring. The unique jujube aroma and the mild sweet aroma of the extract are critical factors that determine product quality and affect consumer accepta...

    Shi-Hao Sun, Guo-Bi Chai, Peng Li, Jian-Ping Xie and Yue Su

    Chemistry Central Journal 2017 11:101

    Published on: 13 October 2017

  12. Research article

    Simultaneous determination of cetirizine, phenyl propanolamine and nimesulide using third derivative spectrophotometry and high performance liquid chromatography in pharmaceutical preparations

    The combination between cetirizine (CET), phenylpropanolamine (PPA) and nimesulide (NMS) under trade name Nemeriv Cp tablet is prescribed for nasal congestion, cold, sneezing, and allergy. Among all published ...

    Fatma Ahmed Aly, Nahed EL-Enany, Heba Elmansi and Amany Nabil

    Chemistry Central Journal 2017 11:99

    Published on: 5 October 2017

  13. Research Article

    Isolation, purification, structural analysis and coagulatory activity of water-soluble polysaccharides from Ligustrum lucidum Ait flowers

    In this study, Ligustrum lucidum flowers as raw material, the extraction, isolation and coagulatory activity of polysaccharides were carried out for the first time. The crude polysaccharide was obtained by hot wa...

    Zhenhua Yin, Wei Zhang, Juanjuan Zhang and Wenyi Kang

    Chemistry Central Journal 2017 11:98

    Published on: 4 October 2017

  14. Research article

    Optimization of phenolics and flavonoids extraction conditions of Curcuma Zedoaria leaves using response surface methodology

    This study focused on maximizing the extraction yield of total phenolics and flavonoids from Curcuma Zedoaria leaves as a function of time (80–120 min), temperature (60–80 °C) and ethanol concentration (70–90 v/v...

    Nur Fauwizah Azahar, Siti Salwa Abd Gani and Nor Fadzillah Mohd Mokhtar

    Chemistry Central Journal 2017 11:96

    Published on: 2 October 2017

  15. Research Article

    Acidic and enzymatic saccharification of waste agricultural biomass for biotechnological production of xylitol

    The plant biomass and agro-industrial wastes show great potential for their use as attractive low cost substrates in biotechnological processes. Wheat straw and corn cob as hemicellulosic substrates were acid ...

    Abdul Ghaffar, Muhammad Yameen, Nosheen Aslam, Fatima Jalal, Razia Noreen, Bushra Munir, Zahed Mahmood, Sadaf Saleem, Naila Rafiq, Sadia Falak, Imtiaz Mahmood Tahir, Muhammad Noman, Muhammad Umar Farooq, Samina Qasim and Farooq Latif

    Chemistry Central Journal 2017 11:97

    Published on: 2 October 2017

  16. Research article

    Synthesis and biological evaluation of tricyclic matrinic derivatives as a class of novel anti-HCV agents

    12N-benzyl matrinic acid analogues had been identified to be a novel scaffold of anti-HCV agents with a specific mechanism, and the representative compound 1 demonstrated a moderate anti-HCV activity. The intensi...

    Sheng Tang, Zong-Gen Peng, Ying-Hong Li, Xin Zhang, Tian-Yun Fan, Jian-Dong Jiang, Yan-Xiang Wang and Dan-Qing Song

    Chemistry Central Journal 2017 11:94

    Published on: 29 September 2017

  17. Research article

    Phenolic compounds, flavonoids, lipids and antioxidant potential of apricot (Prunus armeniaca L.) pomace fermented by two filamentous fungal strains in solid state system

    The use of agricultural and food by-products is an economical solution to industrial biotechnology. The apricot press residues are abounding by-products from juice industry which can be used as substrates in s...

    Francisc Vasile Dulf, Dan Cristian Vodnar, Eva-Henrietta Dulf and Adela Pintea

    Chemistry Central Journal 2017 11:92

    Published on: 21 September 2017

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